Pharm_Geriatrics

Question 1

aripiprazole
trade name = ?
classification = ?

Answer 1

trade name = Abilify

classification = 2nd gen antipsychotic

Question 2

aripiprazole side effects/adverse effects

Answer 2

tardive dyskinesia
dystonia
hyperglycemia/DM
dysphagia, severe

Question 3

risperidone
trade name
subclass

Answer 3

RISPERDAL
antispychotics, 2nd generation
also, bipolar disorder

Question 4

(Aquifer)

what is ginseng known to cause?

Answer 4

hypoglycemia

Question 5

(Aquifer)

gabapentin can cause

Answer 5

sedation

Question 6

(Aquifer)

glyburide and Glynase

Answer 6

are the same medicine

Question 7

(Aquifer)

two factors that can lead to hypoglycemia in elderly

Answer 7

the rate of insulin clearance may decline

counter-regulatory hormonal responses may be lower

Question 8

(Aquifer)

two meds on Beers Criteria for PIM that cause hypoglycemia

Answer 8

glyburide (sulfonylurea)
chlorpropamide

these drugs have very long half-life (10 hrs and 36 hrs respectively)

Question 9

(Aquifer)
what sulfonylurea drug is best for elderly, with a 2-4 hr half life?

and what pt education should be given for it?

Answer 9

GLIPIZIDE

take with food to help prevent hypoglycemia

Question 10

(Aquifer)

two drugs with narrow therapeutic windows that should be watched closely in the elderly with reduced renal clearance

Answer 10

digoxin

insulin

Question 11

(Aquifer)

a long acting insulin

Answer 11

glargine

long half-life, allows once-a-day dosing

Question 12

(Aquifer)

a contraindication for metformin

Answer 12

eGFR < 30

Question 13

(Aquifer)
saxagliptin
class
approximate A1c reduction

Answer 13

DPP-4 inhibitor
~0.5% A1c lowering

(very low risk of hypoglycemia)

Question 14

(Aquifer)

two side effects of pioglitazone

Answer 14

may cause fluid retention and worsening edema

Question 15

(Aquifer)

classification of GLIMEPIRIDE

Answer 15

sulfonylurea

Question 16

(Aquifer)

classification of GLYBURIDE

Answer 16

sulfonylurea

Question 17

(Aquifer)

two kidney contraindications of glyburide

Answer 17

CKD

eGFR < 60

Question 18

(Aquifer)

don’t combine Bactrim (TMP-SMX) with what?

Answer 18

glyburide

the combination further increases the unbound active conc of glyburide, which increases the hypoglycemic effect of glyburide, leading to hypoglycemia (to the point of causing a seizure!)

Question 19

(Aquifer)

two drugs common in the elderly that can be associated with memory impairments?

Answer 19

atenolol

levothyroxine