Pharm Toxicology Flashcards by Elyse Kohl

Cornea: whorl k

Chloroquine
Hydroxychloroquine
Amiodarone
Indomethacin
Tamoxifen

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Cornea: dry eye

BAK (incl glaucoma meds)

Anti-cholinergics

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Cornea: SPK

Isotretinoin/accutane
Topical aminoglycosides (TobraGent)

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Cornea: endo/descemet’s pigment

Promethazine/phenergan
Chlorpromazine
Thioridazine

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Cornea: ocular chrysiasis

Gold salts in stroma

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Cornea: delayed healing

Topical AND oral steroids

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Lens: anterior subcapsular

Miotics (vacuoles)
Thioridazine
Amiodarone (deposits)
Chlorpromazine

*also atopic derm (shield)

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Lens: PSC

Corticosteroids (dose dependent; esp in Hispanics)

*also x-rays/radiation

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Conj and lids: Isotretinoin/Accutane

Blepharoconjunctivitis
Dryness
Lid edema

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Conj and lids: subconj hemorrhage

NSAIDs
Coumadin
Clopidogrel (plavix)
Dipyridamole (~aspirin)

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Conj and lids: sulfonamides

SJS

Lid edema

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Conj and lids: pigmented cysts

Tetracyclines

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Conj and lids: subconj hemorrhage and conj hyperemia

Viagra (sildenafil)

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Conj and lids: prostaglandin analogs

Conj hyperemia
Incr growth/pigmentation of lashes
Incr pigmentation of periorbital skin

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Conj and lids: tamiflu

Conjunctivitis (1%)

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Lacrimal system: anticholinergic effects

Anticholinergics: STop ACH
Antidepressants: TCAs = amitriptyline, imipramine
Antihistamines: chlorpheniramine, brompheniramine, diphenhydramine, promethazine (phenergan)
Antipsychs: chlorpromazine, thioridazine

Pupil size: mydriasis

Anticholinergics (STop ACH, antihistamines, antidepressants, antipsychs)

Dopamine agonists: methylphenidate & dextroamphetamine (ADHD), amantadine & bromocriptine (Parkinson’s)

Pupil size: miosis

Opiates: morphine, heroine, codeine

AChase inhibitors: MG and Alzheimers drugs (edrophonium, neostigmine, echothiophate, pyridostigmine, donepezil)

EOMS, eye movements: nystagmus

Phenytoin (dilantin)
Phenobarbital (luminal)
Salicylates = NSAIDs
Alcohol: end-point

EOMS, eye movements: diplopia

Antidepressants
Antianxiety
Phenytoin

EOMS, eye movements: smooth pursuits

Alcohol

EOMS, eye movements: oculogyric crisis

Phenothiazines (chlorpromazine, thioridazine)

Cetirizine (zyrtec)

Sclera, uvea: blue sclera

Minocycline

Corticosteroids

Sclera, uvea: secondary angle closure

Topiramate (topamax): choroidal swelling moves uvea forward, also causes myopia

Optic nerve: digoxin

Retrobulbar ON BY color defects Entopic/snowy