PHARM - Thyroid Drugs - Staud

Question 1

Propranolol

Class:

MOA:

Ind:

Answer 1

Beta-blocker

blocks conversion of T4 to T3 in peripheral tissues

Thyroid Storm (reduce heart rate and tremor)

Question 2

Methimazole

MOA:

Ind:

Adverse:

Answer 2

blocks iodide organificiation by blocking Thyroperoxidase, (tyrosine not converted to T4/T3, no iodidne added)

Graves Dz, Hyperthyroidism

Agranulocytosis = severe low WBC (esp neutrophils)

Aplastic Anemia, Liver Inflamm

Question 3

What is the most important screening test for Hyper- and Hypothyroidism?

Answer 3

TSH (Thyrotropin)

Question 4

Levothyroxine

Class:

MOA:

Ind:

Adverse:

Key Drug-Drug interactions:

Answer 4

Exogenous T4

coverted to T3 by body

Hypothyroidism

Weight loss, heat intolerance, sweating, anxiety

Cholestyramine*, antacids, iron, sucralfate

Question 5

Radioactive Iodine = I¹³¹

MOA:

Ind:

CI:

Answer 5

Taken up by Thyroid, destroys cells

Thyroid Cancer

Pregnant Women*

Question 6

Atenolol

Class:

Ind:

Positives:

Answer 6

Beta-blocker

Thyroid Storm, Graves dz*

*listed as primary tx in Clin Med

Fewer cerebral side effects than Propranolol, (though propranolol is more widely studied and used)