pharm test 1 Flashcards
what is pharmacology. and what is medical pharmacology
study of chemical interactions with living systems. medical pharmacology is the study of substances used to prevent, diagnose, and treat diseases
what is toxicology and who is the father
component of pharmacology; undesirable effects of chemicals on living systems. not SS. Paracelsus- “The dose makes the poison”
difference between toxins and poisons
toxins- biological substances
poisons- not biological. can be agonist or antagonist
describe early medicine
prehistoric- shamanism, animism, spiritualism, divination. ayurvedic is indian medicine and then traditional chinese medicine is still going strong
in ancient Egypt Imhotep is first recorded physician
rod of Asclepius
Materia Medica
precursor to pharm textbook; first medical textbook in western world. author is Dioscorides but probs multiple authors. body of knowledge on plants and medical substances. discussed preparation and use and precursor to pharmacology
Modern Pharmacology
adherence to scientific principals and controlled drug trials to get rid of placebos. evaluation of therapeutic claims and got rid of worthless medicines. about 70 groups of drugs
pharmacodynamics
what the drug does to the body
agonist- drug binds to receptor and activates response. effect may be greater or lesser than native ligant
antagonist- bind to receptor and prevent binding of native ligand; does not elicit response
pharmacokinetics
what the body does to the drug
Absorption
Distribuition
Metabolism
Excretion
pharmacogenetics
looking at genetic profile to see how you will respond to drug
agonist
elicits response from receptor aka will have downstream response. response is usually similar to endogenous ligand of body. can be more or less effective than natural ligand
antagonist
blocks the endogenous ligand or blocks receptor from working; shuts down receptor. does not elicit response
organic compounds
C, O, or H. carbs, lipid, proteins
drug size
expressed in molecular weight usually daltons. most drugs 100-1000 MW and if >1000 then cannot diffuse easily so need to give straight into blood stream
receptor interactions
appropriate size, electrical charge(polar is full or half charge), shape, and atomic composition are all part of lock and key mechanism