Pharm Terms

Question 1

The intended effect of a drug (pain relief or sedation etc.)

Answer 1

Therapeutic Effect

Question 2

The ability if a drug to produce a desired therapeutic effect

Answer 2

Efficacy

Question 3

The tendency of a drug to combine with a matching receptor

Answer 3

Affinity

Question 4

A drug that binds to a receptor site and initiates a cellular response. possesses efficacy and affinity

Answer 4

Agonist

Question 5

A drug that is able to bind to a receptor site to prevent stimulation of the receptor - has affinity but no efficacy

Answer 5

Antagonist

Question 6

The recommended amount of a drug that should be used to obtain the desired clinical effect

Answer 6

Therapeutic Dose

Question 7

The amount of drug that reaches systemic circulation to produce effect required - affected by absorption, inactivation, blood flow, volume

Answer 7

Bioavailability

Question 8

Administering sufficient quantities of a drug to attain therapeutic levels quickly

Answer 8

Loading Dose

Question 9

The amount of drug required to keep a desired mean steady-state concentration in the tissues

Answer 9

Maintenance Dose

Question 10

Time necessary to reduce an initial dose by half characteristics such as plasma protein binding, metabolism, and elimination. These processes remove drug from the blood important for determining frequency of dosing

Answer 10

Half-life

Question 11

This is the dose at which 50% of the test animals die

Answer 11

Median Lethal Dose (LD50)

Question 12

This is the dose at which 50% of the test animals show the desired affect

Answer 12

Median Effective Dose (ED50)

Question 13

This is the ratio of the LD50 to ED50 that gives relative indication as to the safety of a drug

Answer 13

Therapeutic Index

Question 14

Occurs when 2 drugs together produce an effect greater than the 2 drugs alone could produce

Answer 14

Synergism

Question 15

Like synergism but one drug has no affect but can increase the effect of the other drug

Answer 15

Potentiation

Question 16

Progressive decrease in effectiveness of a drug after time - requires increasing drug amount to produce the same effect due to increased metabolism of the drug by the body

Answer 16

Tolerance

Question 17

A rapid decrease in response to a drug

Answer 17

Tachyphylaxis

Question 18

An allergic or immune-mediated reaction to a drug

Answer 18

Hypersensitivity

Question 19

Drug effects other than those that were intended

Answer 19

Side Effect

Question 20

Drugs that are known to cause birth defects

Answer 20

Teratogens

Question 21

Any drug/substance that produces cancer or increases the risk of developing cancer

Answer 21

Carcinogens