PHARM STUDY GUIDE Chapters 1, 2,3,5 Flashcards
Generic Name (Acetylsalicylic-) What is Trade Name?
Classification for Acetylsalicylic
Bayer-Aspirin •Bufferin
Platelet aggregator inhibitor, Nonsteroidal anti-inflammatory
Generic name (Adenosine) What is Trade name?
Classification for Adenosine
Adenocard
Antidysrhythmic
Generic Name (ALBUTEROL) What is Trade Name?
Classification for ALBUTEROL
Proventil -Ventolin
Sympathomimetic-Bronchodilator-Beta2 agonist
Generic Name (AMIODARONE) What is Trade Name?
Classification for AMIODARONE
Cordarone
Anti-dysrhythmic
GENERIC NAME (ATROPINE) What is Trade Name?
Classification for (ATROPINE)
NONE
Anticholinergic •Parasympathetic blocker• Antidote
Generic Name (CALCIUM CHLORIDE) What is Trade Name?
Classification for (CALCIUM CHLORIDE)
NONE
Electrolyte
Generic Name (ACTIVATED-CHARCOAL) What is Trade Name?
Classification for (ACTIVATED-CHARCOAL)
Actidose •EZ-Char •Liqui-Char®
Adsorbent
Generic Name (DEXTROSE) What is Trade Name?
Classification for (DEXTROSE)
D50
•Carbohydrate• Antihypoglycemic
Generic Name (DIAZEPAM) What is Trade Name?
Classification for (DIAZEPAM)
Valium
•Benzodiazepine• Anticonvulsant• Sedative• Hypnotic
Generic Name (DILTIAZEM) What is Trade Name?
Classification for (DILTIAZEM)
Cardizem
•Calcium channel blocker•
Anti-dysrhythmic
Generic Name(DIPHENHYDRAMINE) What is Trade Name?
Classification for (DIPHENHYDRAMINE)
Benadryl
•Antihistamine• Anticholinergic
Generic Name (DOPAMINE) What is Trade Name?
Classification for (DOPAMINE)
Intropin
•Sympathomimetic• Vasopressor Adrenergic agonist
Generic Name (EPINEPHRINE) What is Trade Name?
Classification for (EPINEPHRINE)
Adrenalin
Sympathomimetic
Generic Name (ETOMIDATE) What is Trade Name?
Classification for (ETOMIDATE
Amidate
Anesthesia induction agent• Hypnotic•Sedative
Generic Name (FENTANYL) What is Trade Name?
Classification for (FENTANYL)
Duragesic®•Sublimaze®
Narcotic analgesic• Narcotic agonist
What is Definition of PHARMACOKINETICS
refers to how the body acts on a medication,
including how the drug is absorbed into the bloodstream,
how the drug is distributed,
how the body metabolizes, and how the body eliminates the drug.
(WHAT THE BODY DOES TO THE DRUG)
What is Definition of PHARMACODYNAMICS
How a drug works and interacts with various receptors, other drugs and enzyme systems within the body.
(WHAT THE DRUG DOES TO THE BODY)
What is Definition of PHARMACOLOGY
Study of biochemical and physiologic properties of medications
What is Definition of THERAPEUTIC INDEX (TI)
is the measurement of the relative safety of a drug.
TWO factors used to determine safety of a drug.
EFFECTIVE DOSE AND LETHAL DOSE.
What is Definition of BIOAVAILABILITY
is the percentage of an administered drug that is available in the blood stream to act at the target tissue
6 PATIENTS RIGHTS
Right Patient, Right Drug/Right Indication Right Dose Right Route Right Time Right Documentation
What is a Side Effect?
Benign annoyances
Headaches
Nausea
Drowsiness
Often treated by reducing dosage or eliminating offending medication
Enteral administration
Absorbed through GI tract
Given orally or rectally
Must first pass through liver before being
distributed THROUGHOUT the body.
THINK ABOUT YOUR GROSS AND NET PAYCHECK
Parenteral Route
Medications are drugs that bypass the GI tract.
Rapidly available and circulate throughout body in minutes
IV is preferred route for cardiac medications in ALS situations
Half life
Time required for concentration of medication in bloodstream to decrease to half its original level.
Duration of action
Amount of time a single dose produces desired effect
buccal administration
absorption across mucous membranes or the skin Example glucose gel
What are some common causes of (ALOC)?
Cardiac arrhythmia Diabetic emergency SeizureToxic ingestion or overdose StrokeTraumatic brain injury
generic
Registered with Food and Drug Administration (FDA)
Pharmacopeia-National
(Written in lower case)
Trade Name
Created by pharmaceutical companies
Always (begin with a capital letter)
First pass metabolism
Drug is partially metabolized
Reduces amount of medication
THINK ABOUT YOUR GROSS AND NET PAYCHECK
Passive diffusion
Occurs when medications penetrate cells by diffusing through cells membranes
Think of breathing!
Passive transport
Occurs when drug molecule moves down concentration gradient
Drug moves from area of high concentration to area of low concentration
Receptors
Are sites on various tissue to which some drugs bind to exert their desired physiologic effects.
Think about a key and lock.
The DRUG is the key.
The RECEPTOR is the lock.
Absorption
is the movement of a medication from the point of administration.
Example ( GI tract skin muscle) into the bloodstream for movement throughout the body.
Drug excretion
Removal of drug or metabolite from body
Kidney is typically the organ responsible for removal
Onset of action
Time interval from administration to desired effect
Reversible binding
Occurs when drug is able to separate from cell’’s receptors
When drug is removed from receptor, effect of drug stops
Irreversible binding
Some medications are unable to separate from receptor after they bind to receptor they bind to receptor.
ASA
PLAVIX
MAOI’’s
Agonist
Drug that produces desired physiologic effect upon binding with receptor
Turn things on
Antagonist
Drug that diminishes or eradicates physiologic effect of agonist
Turn things off
Adverse effects
Considered serious
Renal failure
Bleeding
Bone marrow suppression
Progression of heart disease
Cholinergic agonists
Drugs that act on the parasympathetic nervous system.
adrenergic agonists
Medications that exert effects on the sympathetic nervous system.
Beta 1 receptors
Cardiovascular in nature they are found on the heart.
increase heart rate and contractility.
Increases cardiac output
Beta 2 receptors
located on the bronchial smooth muscle.
increases the diameter of the bronchial tree.
Stimulation relaxes bronchial smooth muscle
(Respiratory emergencies)
Alpha1
Primarily located on peripheral blood vessels
Stimulation results in vasoconstriction and elevation systemic BPs
Alpha2
Located on nerve endings
Provide negative feedback to nerves in sympathetic nervous system
Signals process when goal or target is reached
Sympathomimetic
physiological effects characteristic
of the sympathetic nervous system
by promoting the stimulation of sympathetic nerves.
Chronotropic
EFFECTS THE HEART RATE
POSTIVE INCREASES
NEGATIVE DECREASES
INOTROPIC
EFFECTS THE SQUEEZE OF THE HEART MUSCLE
POSTIVE MAKE SQUEEZE HARDER
NEGATIVE DECREASE THE INTENSITY OF CARDIAC SQUEEZE
ISOTONIC
Fluids that have equal osmotic pressure with the body under normal conditions.
HYPOTONIC
Fluids that have less osmotic pressure.
HYPERTOMIC
Fluids have greater than normal osmotic pressure,
MICRO DRIP
Administer 60 gtt/mL
Used with adrenergic agents and cardiac anti-arrhythmics
Used with children sensitive to large amounts of IV fluids
MACRO DRIP
Variety of sizesDrip factors of
10, 12, 15, and 20 gtt/mL
For any amount of blood loss,
You need at least 3x amount of crystalloid
is required to increase intravascular volume to compensate.
Intracellular fluid (ICF)
Found inside cells
Extracellular fluid (ECF)
Found between cells and inside blood vessels
Active transport
Requires macromolecule to assist in transport
Capable of reaching point of saturation.