Pharm side effects

Question 1

adrenocortical insufficiency

Answer 1

HPA suppression secondary to glucorticord withdrawal

Question 2

hot flashes

Answer 2

tamoxifen, clomiphene

Question 3

hyperglycemia

Answer 3

tacrolimus, protease inhibitors, niacin, HCTZ, corticosteroids
Taking Pills Necessitates Having blood checked

Question 4

hypothyroidism

Answer 4

lithium, amiodarone, sulfonamides

Question 5

gynecomastia

Answer 5

spironolactone, digitalis, cimetidine, alcohol, estrogens, ketoconazole

Question 6

acute cholestatic hepatitis, jaundice

Answer 6

erythromycin

Question 7

diarrhea

Answer 7

metformin, erythromycin, colchicine, orlistat, acarbose

Question 8

focal to massive hepatic necrosis

Answer 8

halothane, amanita phalloides, valproic acid, acetaminophen

Question 9

hepatits

Answer 9

rifampin, isoniazid, pyrazinamide, statins, fibrates

Question 10

pancreatitis

Answer 10

didanosine, corticosteroids, alcohol, valproic acid, azathioprine, diuretics

Question 11

pseudomembranous colitis

Answer 11

clindamycin, ampicillin, cephalosporins

Question 12

agranulocytosis

Answer 12

gangciclovir, clozapine, carbamazepine, colchicine, methimazole, PTU

Question 13

aplastic anemia

Answer 13

carbamazepine, methimazole, NSAIDs, benzene, chloramphenicol, PTU

Question 14

direct coombs positive hemolytic anemia

Answer 14

methyldopa penicillin

Question 15

gray baby syndrome

Answer 15

chloramphenicol

Question 16

hemolysis in G6PD deficiency

Answer 16

isoniazid, sulfonamides, dapsone, primaquine, aspirin, ibuprophen, nitrofurantoin

Question 17

megaloblastic anemia

Answer 17

phenytoin, MTX, sulfa drugs

Question 18

thrombocytopenia

Answer 18

heparin

Question 19

thrombotic complications

Answer 19

OTC, HRT, combined with smoking

Question 20

fat redistribution

Answer 20

protease inhibitors, glucocorticoids

Question 21

gingival hyperplasia

Answer 21

phenytoin, CCB, cyclosporine

Question 22

hyperuricemia

Answer 22

pyrazinamide, thiazide, furosemide, niacin, cyclosporine

Question 23

myopathy

Answer 23

fibrates, niacin, colchicine, hydroxychloroquine, INFa, penicillamine, statins, glucocorticoids

Question 24

osteoporosis

Answer 24

corticosteroids, heparin

Question 25

photosensitivity

Answer 25

sulfonamides, amiodarone, tetracyclines, 5-FU

Question 26

rash (stevens johnson)

Answer 26

anti-epileptic drugs (lamotrigine), allopurinol, sulfa drugs, penicillin Steven johnson has epileptic allergy to sulfa drugs and penicillin

Question 27

SLE like syndrome

Answer 27

sulfa, hydralazine, INH, procainamide, phenytoin, etanercept | SHIPPE

Question 28

teeth discoloration

Answer 28

tetracycline

Question 29

tendonitis, tendon rupture, cartilage damage

Answer 29

fluoroquinolones

Question 30

cinchonism

Answer 30

tinnitus, HA, deafness | quinidine, quinine

Question 31

parksinson like syndrome

Answer 31

antipsychotics, reserpine, metoclopramide

Question 32

seizures

Answer 32

INH (vitamin b6 deficiency), bupropion, imipenem/cilastatin, enfluane

Question 33

tardive dyskinesia

Answer 33

antipsychotics, metoclopramide

Question 34

diabetes insipidus

Answer 34

lithium, demeclocycline

Question 35

fanconi syndrome

Answer 35

expired tetracycline

Question 36

hemorrhagic cystitis

Answer 36

cyclophosphamide, ifosfamide | prevent with mesna

Question 37

interstitial nephritis

Answer 37

methicillin, NSAIDs, furosemide

Question 38

SIADH

Answer 38

carbamazepine, cyclophosphamide, SSRI | cant concentrate serum sodium

Question 39

dry cough

Answer 39

ace inhibitors

Question 40

pulmonary fibrosis

Answer 40

bleomycine amiodarone, busulfan, MTX

Question 41

antimuscarinic

Answer 41

atropine, TCA, H1 blockers, antipsychotics

Question 42

disulfram like reaction

Answer 42

metronidazole certain cephalosporin, griseofulvin, procarbazine, first gen sulfonylureas

Question 43

nephrotoxicity/ototoxicity

Answer 43

aminoglycosides, vancomycin, loop diuretics, cisplatin | cisplatin might respond to amifostine

Question 44

sulfa drugs

Answer 44

probenecid, furosemide, acetazolamide, celecoxib, thiazides, sulfonamide antibiotics, sulfasalazine, sulfaonylureas

Question 45

CYP450 inducers

Answer 45

``` guinness, coronas, PBRS induce chronic alcoholism griseofulvin carbamazepine phenytoin/phenobarbital rifampin st. johns wort nevirapine ```

Question 46

CYP450 substrates

Answer 46

anti-epileptics theophylline warfarin OCPs

Question 47

CYP450 inhibitors

Answer 47

``` CRACK AMIGOS cirpo ritonavir amiodarone cimetidine ketoconazole acute alcohol abuse macrolides (except azithromycin) INH grapefruit jiuce sulfonamides quinidine ```

Question 48

coronary vasospasm

Answer 48

cocaine, sumatriptan, ergot

Question 49

cutaneous flushing

Answer 49

``` VANC vancomycin adenosine niacin CCB ```

Question 50

dilated cardiomyopathy

Answer 50

anthracyclines (doxo/daunor) | prevent with dexrazoxane

Question 51

torsades de pointes

Answer 51

``` Class III and Ia macrolides antipsychotics TCA Tx with Mg ```