Pharm receptors

Question 1

a-1, protein class?

Answer 1

Gq–> phospholipase C –> IP3 & DAG

Question 2

a-1 major functions

Answer 2

Increase smooth muscle CONTRACTION, MYDRIASIS (dilated), increase intestinal and bladder sphincter muscle CONTRACTION.

Question 3

a-2, protein class?

Answer 3

Gi–> decreases cAMP and Protein kinase A

Question 4

a-2 major functions

Answer 4

Decrease Sympathetic, Insulin, Lipolysis, Aqueous humor production.

Increase Platelet aggregation

Question 5

B-1, class protein?

Answer 5

Gs–> increases cAMP and Protein kinase A = increase calcium in the heart.

Question 6

B-1 major functions

Answer 6

Increase HR, Contractility, Renin release, Lipolysis.

Question 7

B-2, class protein?

Answer 7

Gs–> increases cAMP and Protein kinase A = increase calcium in the heart.

Question 8

B-2 major functions

Answer 8

Vasodilation, Bronchodilation

Increase Lipolysis, Insulin release, Aqueous humor production

Decrease Uterine tone, Ciliary muscle tone (=relaxation)

Question 9

M-1, class protein?

Answer 9

Gq–> phospholipase C –> IP3 & DAG

Question 10

M-1 major functions

Answer 10

CNS, enteric nervous system

Question 11

M-2, class protein?

Answer 11

Gi–> decreases cAMP and Protein kinase A

Question 12

M-2 major functions

Answer 12

Decrease HR and contractility of Right Atria

Question 13

M-3, class protein?

Answer 13

Gq–> phospholipase C –> IP3 & DAG

Question 14

M-3 major functions

Answer 14

Increase Exocrine gland secretions, Lacrimation, Salivation, Gastric acid, Gut peristalsis, Bladder contraction, Bronchoconstriction, Pupillary sphincter muscle contraction, Miosis (pinpoint pupil), Ciliary muscle contraction (accommodation).

Question 15

D-1, class protein?

Answer 15

Gs–> increases cAMP and Protein kinase A = increase calcium in the heart.

Question 16

D-1 major functions

Answer 16

Relaxes renal vascular smooth muscle

Question 17

D-2, class protein?

Answer 17

Gi–> decreases cAMP and Protein kinase A

Question 18

D-2 major functions

Answer 18

Modulates transmitter release (brain)

Question 19

H-1, class protein?

Answer 19

Gq–> phospholipase C –> IP3 & DAG

Question 20

H-1 major functions

Answer 20

Increases nasal mucus, bronchial mucus, vascular permeability, contraction of bronchioles, pruritus, pain.

Question 21

H-2, class protein?

Answer 21

Gs–> increases cAMP and Protein kinase A = increase calcium in the heart.

Question 22

H-2 major functions

Answer 22

Increases gastric acid secretion

Question 23

V-1, class protein?

Answer 23

Gq–> phospholipase C –> IP3 & DAG

Question 24

V-1 major functions

Answer 24

Increases Vascular smooth muscle contraction

Question 25

V-2, class protein?

Answer 25

Gs–> increases cAMP and Protein kinase A = increase calcium in the heart.

Question 26

V-2 major functions

Answer 26

Increases water permeability and reabsorption in the collecting tubules of kidney.

Question 27

Gq receptors

Answer 27

HAVe 1 M&M

H1, a1, V1, M1, M3

Question 28

Gi receptors

Answer 28

MAD 2’s

M2, a2, D2

Question 29

Gs receptors

Answer 29

The leftovers

B1, B2, D1, H2, V2