Pharm Quiz #3 Flashcards

1
Q

(3) Antibiotic Classes that bind to 50s Ribosomal Subunit

A
  1. Macrolides
  2. Lincoamides
  3. Oxazolidinones
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2
Q

(2) Antibiotic Classes that bind to 30s Ribosomal Subunit

A
  1. Tetracyclines

2. Aminoglycosides

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3
Q

Antibiotic class that Inhibits Dihydrofolate Reductase in Protozoa.

A

Pyrimethamines— Pyrimidine

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4
Q

Antibiotic Class that Blocks folate production and folate synthesis by “pretending to be PABA”

A

Sulfonamides

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5
Q

Fosfomycin, Nitrofuration, and Phenazopyridine are all examples of ____ Drugs. (3 letters)

A

UTI drugs

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6
Q

This drug binds to cell wall precursors (Lipid II) and makes them too large for incorporation.

A

Vancomycin

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7
Q

MOA of Mupirocin?

A

Inhibits bacterial Protein synthesis

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8
Q

New expensive C. Diff medication?

A

Bezlotoxumab (-mab) = expensive

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9
Q

Old school drug that Increases cell membrane permeability and Neutralizes Endotoxins?

A

Colistin (Polymyxin E)

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10
Q

Antibiotic class that inhibits bacterial synthesis by Inhibiting DNA gyrase and Topoisomerase IV

A

Fluoroquinolones

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11
Q

Antibiotic Duo that Inhibit early and late protein synthesis?

A

Quinupristin/Dalfopristin (Synercid)

Q = late D = early (in ribosome)

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12
Q

Name 2 Oxazolidinones

A
  1. Linezolid

2. Tedizolid

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13
Q

Name 4 Macrolides

A
  1. Erythromycin
  2. Clarithromycin
  3. Azithromycin
  4. Fidaxomicin
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14
Q

Name the only Lincoamide

A

Clindamycin

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15
Q

Name 5 Aminoglycosides

A
  1. Amikacin
  2. Gentamicin
  3. Neomycin
  4. Streptomycin
  5. Tobramycin
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16
Q

What drug could you use to decrease buring, dysuria, and frequency with urination?

A

Phenazopyridine (Pyridium)

-Urinary tract Analgesic

17
Q

Antibiotic class that interferes with Cross-Linking of peptidoglycan in bacterial cell walls.

A

Lipoglycopeptides

18
Q

Name 2 Lipoglycopeptides

A
  1. Oritavancin

2. Dalbavancin

19
Q

Name 2 Oxazolidinones

A
  1. Linezolid

2. Tedizolid

20
Q

What kind of molecules indicate that Baceria are present in Urine?

A

Nitrates

21
Q

Name 4 Fluoroquinolones

A
  1. Ciprofloxacin
  2. Levofloxacin
  3. Moxifloxacin
  4. Gatifloxacin
22
Q

Name 5 Tetracyclines

A
  1. Tetracycline
  2. Doxycycline
  3. Minocycline
  4. Demeclocycline
  5. Tigecycline
23
Q

What does Steven-Johnson Syndrome (SJS) affect?

A

Skin and Mucous Membranes (can be fatal)

—-Erythromycins, PCNS, barbituates, Sulfamides

24
Q

What does TENS stand for?

A

Toxic Epidermal Necrolysis

25
Q

Name 4 Sulfonamides

A
  1. Silver Sulfadiazine
  2. Sulfacetamides
  3. Sulfasalazine
  4. Sulfamethoxazole/Trimethoprim
    (trimethoprim = dihydrofolate reductase inhibitor)
26
Q

What drugs cover MRSA?

A
  1. Vancomycin
  2. Oxazolidinones (Linezolid and Tedizolid)
  3. Lipoglycopeptides (Oritavancin and Dalbavancin)
  4. Quinupristin/Dalfopristin
  5. Clindamycin
  6. Sulfamethoxanzole/trimethoprim (skin MRSA)
  7. Moxifloxacin
  8. Mupirocin
27
Q

Drugs to worry about Ototoxicity

A
  1. Aminoglycosides

2. Vancomycin

28
Q

Drug associated with Red Man Syndrome?

A

Vancomycin

29
Q

2 main ADRs associated to Aminoglycosides?

A
  1. Ototoxicity

2. Nephrotoxicity

30
Q

Drugs that affect Pseudomonas?

A
  1. Ciprofloxacin
  2. Nitrofurantoin
  3. Levofloxacin
  4. Colistin (last resort)
31
Q

2 Big P450 interacting drugs

A

Erythromycin

Quinupristin/Dalfopristin

32
Q

2 Big Respiratory antibiotics (bronchitis and pneumonia)

A
  1. Levofloxacin

2. Moxifloxacin

33
Q

2 Classes of drugs that prolong QT.

A
  1. Macrolides

2. Fluoroquinolones

34
Q

Diarrhea in a pill?

A

Clindamycin (good for malaria and anaerobes)

35
Q

(3) Drug Classes requiring renal adjustment?

A
  1. Tetracyclines (for lyme disease)
  2. Fluoroquinolones
  3. Vancomycin