Pharm Quiz 1 Flashcards
What is dose response relationship?
No response if dose is too low
What is it called when the response plateaus
Maximal efficacy or ceiling effect
What is potency
The dose that causes a specific response in a specific magnitude
When a drug causes the response at a lower dose it means it is more or less potent ?
More potent
What is quantal D-R curve ?
Determine dose that causes a specific response in group of subjects and determine drug safety
What two things does quantal Q-R curve measure
Median effective dose (ED50)
median toxic dose (TD 50)
What is median effective dose ?
Dose that causes beneficial effect in half the sample
What is median toxic dose
Dose that causes toxic effect in half the sample
Two analgesic medications are compared and it is found that 10 mg of drug A reduced headache pain by 50% but it takes 60 mg of drug B to cause a similar effect. We conclude that
Drug A is more potent
What is ADME
Absorption
Distribution
Metabolism
Excretion
What is absorption
When the drug must move from sit of administration into another tissue
What are eternal routes of administration
Oral
Lingual
Sublingual
Buccal
Rectal
What are parenteral routes of administration
Injection
Inhalation
Topical
Transdermal
What is bioavailability
The percent of the administered dose that appears in the bloodstream
What is the first pass effect
If the drug is administered orally, some is destroyed in the liver
