Pharm Outline Flashcards

1
Q

Describe the placenta and drug lipid solubility.

A

Lipophilic drugs readily across the placenta to the fetal circulation.

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2
Q

Describe the placenta & drug molecular size/pH.

A

Heparin is a very large (& polar) molecule & is unable to cross the placenta. It is the anticoag of choice in preg women.

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3
Q

Describe the placenta & placental transporters.

A

Many drug transporters have been ID’d w/ incr recognition of their effects on drug transfer to the fetus.

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4
Q

Describe the placenta & PRO binding

A

The degree to which a drug is bound to plasma PROs (esp albumin) may affect rate of transfer & amt transferred.

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5
Q

Effects of corticosteroids on fetus?

A

stimulate fetal lung maturation when preterm birth is expected.

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6
Q

Effects of Phenobarbital on fetus?

A

induces fetal liver enzymes responsible for glucuronidation of bilirubin & lowers the incidence of jaundice

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7
Q

Chronic use of opioids by mother can cause what in the fetus?

A

dependence in the newborn.

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8
Q

ACE inhibitors used in late preg can cause…

A

Fetal drug toxicity

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9
Q

What is the result of fetal drug toxicity?

A

significant & irreversible renal damage in the fetus.

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10
Q

Exposure to diethylstilbestrol may cause what in the female fetus?

A

Incr risk for adenocarcinoma of the vagina after puberty.

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