Pharm Outline

Question 1

Describe the placenta and drug lipid solubility.

Answer 1

Lipophilic drugs readily across the placenta to the fetal circulation.

Question 2

Describe the placenta & drug molecular size/pH.

Answer 2

Heparin is a very large (& polar) molecule & is unable to cross the placenta. It is the anticoag of choice in preg women.

Question 3

Describe the placenta & placental transporters.

Answer 3

Many drug transporters have been ID’d w/ incr recognition of their effects on drug transfer to the fetus.

Question 4

Describe the placenta & PRO binding

Answer 4

The degree to which a drug is bound to plasma PROs (esp albumin) may affect rate of transfer & amt transferred.

Question 5

Effects of corticosteroids on fetus?

Answer 5

stimulate fetal lung maturation when preterm birth is expected.

Question 6

Effects of Phenobarbital on fetus?

Answer 6

induces fetal liver enzymes responsible for glucuronidation of bilirubin & lowers the incidence of jaundice

Question 7

Chronic use of opioids by mother can cause what in the fetus?

Answer 7

dependence in the newborn.

Question 8

ACE inhibitors used in late preg can cause…

Answer 8

Fetal drug toxicity

Question 9

What is the result of fetal drug toxicity?

Answer 9

significant & irreversible renal damage in the fetus.

Question 10

Exposure to diethylstilbestrol may cause what in the female fetus?

Answer 10

Incr risk for adenocarcinoma of the vagina after puberty.