Pharm Outline Flashcards
Describe the placenta and drug lipid solubility.
Lipophilic drugs readily across the placenta to the fetal circulation.
Describe the placenta & drug molecular size/pH.
Heparin is a very large (& polar) molecule & is unable to cross the placenta. It is the anticoag of choice in preg women.
Describe the placenta & placental transporters.
Many drug transporters have been ID’d w/ incr recognition of their effects on drug transfer to the fetus.
Describe the placenta & PRO binding
The degree to which a drug is bound to plasma PROs (esp albumin) may affect rate of transfer & amt transferred.
Effects of corticosteroids on fetus?
stimulate fetal lung maturation when preterm birth is expected.
Effects of Phenobarbital on fetus?
induces fetal liver enzymes responsible for glucuronidation of bilirubin & lowers the incidence of jaundice
Chronic use of opioids by mother can cause what in the fetus?
dependence in the newborn.
ACE inhibitors used in late preg can cause…
Fetal drug toxicity
What is the result of fetal drug toxicity?
significant & irreversible renal damage in the fetus.
Exposure to diethylstilbestrol may cause what in the female fetus?
Incr risk for adenocarcinoma of the vagina after puberty.