PHARM OMT EXAM YR 4 Flashcards
ASA DOSE
81, 162, 325, 500mg OTC
ASA Contraindications
NSAID allergy, viral infection in children/teens, 3rd Tri pregnancy
ASA side effects
GI upset/bleed, prolonged bleeding time, anaphylaxis, salycylism
ASA interactions
anticoags, hypoglycemics, methotrexate, fish oil/omega 3, flaxseed, gingko biloba, green tea, feverfew, live varicella virus vaccine, DHEA
Ibuprofen (motrin, advicl) derivative
propionic acid
Ibuprofen dose
200mg OTC, 400, 600, 800mg
Ibuprofen Contraindications
ASA allergy, 3rd tri pregnency, CABG
Ibuprofen Side effects
peptic ulcer, GI bleed, edema, renal papillary necrosis, jaundice, hepatitis
Ibuprofen interactions
ASA, anticoags, lithium, methotrexate, feverfew, gingko biloba, ginger, sulfonylureas
Duexis
Ibuprofen + Famotidine
Etodolac (Lodine) Class
Pyranocarboxylic acid derivative
Etodolac doses
200, 300, 400, 500mg; XL 400, 500, 600mg
Etodolac Indications
pain, OA, RA, JRA
Etodolac contraindications
ASA allergy, 3rd tri pregnancy, CABG
Etodolac side effects
GI upset/bleed, edema, asthenia/malaise, dysuria, renal or hepatic toxicity
Etodolac interactions
antacids, ACE inhibitors, diuretics, tobacco, levofloxicin, methotrexate
Ketorolac (toradol) class
acetic acid derivative
Ketorolac dose
10mg PO, 30mg IV, 60mg IM, 15mg/ml, 30mg/ml
Ketorolac indications
severe/acute pain-IM/IV hospital use 5 days or less
Ketorolac contraindications
active PUD, CABG, renal impairment, CVA, headache, nausea
Ketorolac side effects
edema, rash, HTN, palpitations, thrombocytopenia, pulmonary edema
Ketorolac interactions
antidepressants
Naproxen (Naprosyn, Aleve) Class
Arylacetic acid derivative
Naproxen dose
250mg (OTC), 375, 500mg
Naproxen indications
mild to mod pain, OA, RA, fever, JRA
Naproxen Contraindications
ASA allergy, 3rd trimester pregnancy, CABG
Naproxen Side effects
GI upset/bleed, tinnitus, nephritis syndrome, hepatitis
Naproxen Interactions
protein bound drugs, diuretics, antihypertensives
Diclofenac NA (voltaren) class
Benzeneacetic acid derivative
Diclofenac NA dose
25, 50, 75, 100mg
Diclofenac NA indications
chronic therapy-mild to moderate pain, OA, RA, AS, topical joint treatment
Diclofenac NA contraindications
ASA allergy, 3rd trimester pregnancy, CABG
Diclofenac NA side effects
hepatic enzymes, anaphylactoid rxn, abdominal distention, tinnitus, SJS
Diclofenac NA Interactions
Etoh, antihistamines, SSRIs, coumadin, ACEI
Diclofenac Potassium name
Cataflam- 50mg
Diclofenac + Misoprostal (arthrotec) class
NSAID + Prostaglandin E1 analogue
Arthrotec dose
50/200, 75/200mg
Arthrotec indication
RA, OA, pts at high risk for NSAID ulcer
Arthrotec contraindications
pregnancy category X, CABG
Arthrotec side effects
Diarrhea, dizziness, stomach pain, elevated transaminase levels
Arthrotec interactions
warfarin, cyclosporins, digoxin, diuretics, insulin, lithium, methotrexate, phenobarbitol, ACEI, magnesium containing antacids
Arthrotec prior to start
negative serum preg test 2 weeks prior to start of therapy, start on 2nd or 3rd day of menstrual period and maintain contraception
Celecoxib-celebrex class
Cox 2 Inhibitor
Celecoxib dose
50, 100, 200, 400mg
Celecoxib indications
acute pain, OA, RA, JOA, AS, dysmenorrhea
Celecoxib contraindications
sulfonamide or ASA allergy, 3rd trimester pregnancy, CABG
Celecoxib side effects
Increased AST/ALT, increased risk of cardio events
Celecoxib interactions
fluconazole, ACEI, diruetics, warfarin
Acetaminophen-Tylenol class
analgesic/antipyretic
Tylenol dose
325, 500mg, max dose 4g/day
Tylenol indications
minor aches/pains, fever
Tylenol contraindications
hepatic dysfunction
Tylenol side effects
hepatotoxicity, rash
Tylenol interactions
EtOH, other drugs containing Tylenol, Echinacea, St. Johns Wort
Sumatriptan-imitrex class
selective 5-HT receptor agonist
Sumatriptan dose
25,50,100mg
nasal spray 5,20mg/spray
injection-4, 5mg/0.5ml
Sumatriptan indications
acute treatment migraine or cluster headache
Sumatriptan contraindications
ischemia, CVA
Sumatriptan side effects
tingling, flushing, chest/neck/sinus/jaw discomfort muscle pain, weakness, seizure, serotonin syndrome
Sumatriptan interactions
Ergotamines, SSRIs/SNRIs, St. Johns Wort, feverfew
Eletriptan-Relpax Class
Selective 5HT receptor agonist
Eletriptan dose
20, 40mg
Eletriptan Indications
acute treatment migraine
Eletriptan Contraindications
ischemia, CVA, angina, acute MI, Raynauds, ischemic bowel disease, uncontrolled hypertension, basilar or hemiplegic migraine
Eletriptan Side effects
chest/neck/throat pain, pressure, tightness, asthenia, nausea, dizziness, somnaolence, dysphagia, serotonin syndrome
Eletriptan Interactions
ergotamines, SSRIs/SNRIs, mycins, St Johns Wort, feverfew, grapefruit juice
zolmitriptan-zomig class
triptan selective 5-HT receptor agonist
Zolmitriptan dose
2.5, 5mg tabs nasal spray-5mg spray
zolmitriptan indications
acute treatment migraine
zolmitriptan contraindications
ischemia, CVA, angina, MI, uncontrolled HTN, basilar or hemiplegic migraine
zolmitriptan side effects
chest/neck/throat pain, pressure, tightness, asthenia, nausea, dizziness, somnolence, dysphagia, serotonin syndrome, warm feeling
Nasal spray-taste disturbance
zolmitriptan interactions
ergotamines, SSRIs/SNRIs, MAOIs, cimetidine, acetaminophen, St. Johns Wort, feverfew
Rizatriptan benzoate (maxalt) class
Triptan-selective 5-HT receptor agonist
Rizatriptan dose
5, 10mg
Rizatriptan indications
acute migraine
Rizatriptan contraindications
ischemic heard disease, uncontrolled HTN
Rizatriptan side effects
dizziness, numbness, tingling, serotonin syndrome, chest pain, abdominal pain, tremors
Rizatriptan interactions
5HT-1D agonists/ergotamine, MAOIs, seratonergic agents, tramadol, propranolol
Butalbitol, Acetominophen, Caffeine (Fioricet) Class
Barbiturate plus analgesic
Fioricet Dose
50/750/40mg, 50/500/40mg, 50/325/40mg
Fioricet Indications
Tension/muscle contraction headache
Fioricet contraindications
porphyria
Fioricet side effects
drowsiness, dizziness, paradoxical excitement, respiratory depression, hepatotoxicity
Fioricet interactions
EtOH, anticoagulants, antibiotics, steroids, tricyclics, anti-retroviral protease inhibitors, echinacea, estrogens, progestins, grapefruit juice
Ergotamine tartrate, caffeine-Migergot Class
Ergot alkoloid
Migergot dose
tab-1/100mg
suppository-2/100mg
sublingual
Migergot Indications
migraine-moderate to severe, migraine variant, cluster headache
Migergot contraindications
peripheral vascular disease, CAD, HTN, hepatic/renal dysfunction, sepsis, pregnancy category X
Migergot side effects
vasoconstrictive complications, ergotism, retroperitonial and pleuropulmonary fibrosis, cardiac valve fibrosis, GI upset
Migergot interactions
sympathomimetics, serotonin, dopamine, adrenergic receptors, erythromycin, dihydroergotamine, echinacea, feverfew, Ephedra/Ma Huang, green tea
Isomethaptene mucate (acetaminophen-midrin) class
analgesic, sympathomimetic
Isomethaptene mucate dose
65mg +100mg +325mg
Isomethaptene mucate indications
abortive treatment-mild to mod migraine, tension HA
Isomethaptene mucate CI
Glaucoma, renal dx, HTN, heart and liver Dx, MAOIs
Isomethaptene mucate SE
Dizziness, rash, nausea
Isomethaptene mucate interactions
Seligiline, bromocriptine, pseudophedrein, guaifenesin echinacea
Topiramate-Topamax class
Sulfamate
Topiramate-Topamax Dose
Tabs-25, 50, 100 200mg
Sprinkle capes-15, 25mg
Topiramate-Topamax indications
Migraine Prophylaxis
Topiramate-Topamax CI
Preg category D
Topiramate-Topamax SE
drowsiness, dizziness, ataxia, speech disorder, psychomotor slowing, hypoesthesia, eye pain, kidney stones, hyercholremic acidosis
Topiramate-Topamax interactions
Carbonic anhydrase inhibitors, estrogens, metformin
Pregabalin-Lyrica class
alpha 2 delta ligand
Pregabalin-Lyrica dose
25, 50, 75 100, 150, 200, 225, 300mg
Pregabalin-Lyrica indications
fibromyalgia, post herpetic neuralgia, DM peripheral neuropathic pain
Pregabalin-Lyrica CI
avoid abrupt cessation, renal impairment, suicidal tendencies