Pharm of Dysmenorrhea

Question 1

Two drug treatment options for dysmenorrhea.

Answer 1

Oral contraceptives or prostaglandins

Question 2

NSAID MOA in dysmenorrhea treatment.

Answer 2

NSAIDS inhibit the production of uterine prostaglandins, preventing or alleviating uterine cramping and pain during menstruation.
NSAIDS are COX-1 or COX-2 inhibitors. Some do both (like ibuprofen and naproxen).

Question 3

Difference between COX-1 and COX-2 inhibition.

Answer 3

COX-1 constitutively expressed in most tissues while COX-2 must be induced.
COX-1 generates cytoprotective prostaglandins (prostacyclins, PGE2), COX-2 generates pro-inflammatory prostaglandins.
COX-1 is involved in platelet aggregation.

Question 4

Side effects of NSAIDS associated with COX inhibitors

Answer 4

NSAIDS can cause gastric ulceration, acute renal failure and unwanted clotting.

Question 5

Reason for avoiding NSAIDS in patients with the aspirin triad.

Answer 5

Aspirin Triad:

Aspirin allergy
Asthma
Nasal polyps

Aspirin can exacerbate hypersensitivity reactions in people with asthma.

Question 6

When during a menstrual cycle should NSAIDs be taken?

Answer 6

Take NSAIDs during first 2-3 days of bleeding to inhibit prostaglandin synthesis and avoid a very early pregnancy.