Pharm MOA and buz words from the table Flashcards
what is the MOA of acetaminophen?
CNS anti-prostaglanding, blocks periphreal pain impulse generation! Inhibits hypothalmic heat regulation!
Acetminophen: Kidneys? Liver?
Kideys YES, liver NO
acetaminophen: increases what?
uric acids in the body
acetaminophen with alocohol?
absolutely not!
acetaminophen: max ped dose?
160/5 ml
acetaminophen interacts with which 3 drugs? what does it do?
anticonvulsants
decrease APAP
increase warfarin
what is the MOA for tramadol?
opioid analgesic, mu receptor antagonist and inhibits uptake NE and 5HT-both modify ascending pain pathways
what is the max dose of tramadol in 24 hours?
400mg
if a person with hepatic or renal impairment and wants to take tramadol what do you have to do?
extended release
what is the MOA for ibuprophen?
inhibit COX1 and COX2 enzymes, reducing PG, prostacyclin, thromboxane
what are the contraindications for ALL NSAIDS?! (4)
HTZ, CKD, HF, CVD
what is a contraindication for ibuprophen?
GI bleeding or ulcer!! causes increased bleeding in 20%
what are common side effects of ALL NSAIDS?!
increase BP
fluid retention
Celecoxib side effects…..this is why you must do what monitor?
increased BP
fluid retention
CV disease, increased clotting
this is why CrCl, CBC, LFT, AND EKG!!!
of the NSAIDS, which is better for a patient with a stomache/gastric bleed/ulcer?
celecoxib since only COX-2 involved
what is the MOA for methotrexate?
[dy at the thought of spiders!!]
inhibits dihydrofolate reductase and DNA production, inhibits production of cytokines
when do you use methotrexate?
recent RA
what is the pregnancy warning for methotrexate?
X
DO NOT GET PREGNANT!!
what are common sideffects of methotrexate? (6)
arachnoiditis, motor paralysis, CN palsey, coma, pulmonary fibrosis, SJS
when should you not use methotrexate in a patient?
AIDS, alcoholic liver disease, peptic ulcer disease, ulcerative colitis
what two things should you not use methotrexate with?
live vaccines and ethanol!
what is the mode of action of hydroxychloroquine?
possibly suppression of T cell response to mitogens
what are the indications for hydroxycholoroquine?
SLE, RA, malaria
what are interesting things hydroxychloroquine can cause?
nightmares, ocular toxiticity (need eyes checked q6-12 months)