Pharm III--CV Drugs/Antianginal and IHD drugs

Question 1

This class of drugs actiavtes MLC phosphatse and deactivates MLCK, thus reducing preload and afterload

Answer 1

What are organic nitrates?

Question 2

This class of drugs reduce preload and affect MVO2 much more than they reduce afterload

Answer 2

What are organic nitrates?

* Enzymes resposnible for converting nitrates are expressed more in veins than in arteries and arterioles

Question 3

What is the principal beneficial effect of organic nitrates in vasospastic angina?

Answer 3

Dilation of large coronary vessels

Question 4

Thes best way to prevent or reverse tolerance to nitrates is to ______

Answer 4

Provide nitrate free periods to the body. Sustained relaese nitrates lead to tolernace, not rapid release

Question 5

The principal antianginal benefit of nitrates in classical angina is to affect ____

Answer 5

Myocardial oxygen demand by reducing preload

Question 6

What is the most significant side effect of nitrates in patients with angina?

Answer 6

Reflex tachycardia and possible increase in MVO2

Question 7

Describe the use of nitrates in CHF

Answer 7

Reduce venous congestion and work of the heart by reducing preload , especially useful in acute pulmoanry edema

Question 8

The only class of drugs that has been shown to impove long-term survival in patients with angina

Answer 8

Beta-blockers

Question 9

Methemoglobin formation by organic nitrates is useful in the treatment of _____

Answer 9

Cyanide poisoning

Question 10

This class of drugs is effective in the management of stable angina by reducing MVO2, but is contrainidcated in patients with variant angina

Answer 10

What are non-selective beta blockers?

Question 11

List major hemodynmic effects of verapamil

Answer 11

HR reduced

AV conduction reduced

Contractility reduced

Afterload reduced