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Women's Health > Pharm I > Flashcards

Pharm I Flashcards

1
Q

what is the most effective treatment for vasomotor symptoms?

A

estrogen

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2
Q

what type of estrogen is preferred, oral or transdermal?

A

transdermal

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3
Q

your pt has CV risk factors like hypertension and she is post menopausal. would you give her oral or transdermal estrogen?

A

transdermal

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4
Q

what’s a major benefit for transdermal estrogen in post menopausal patients as compared to oral?

A

lower incidence of DVT

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5
Q

CIs of estrogen therapy (7)

A
  1. hx of thromboembolic dz
  2. endometrial cancer
  3. breast cx
  4. pregnancy
  5. liver dz
  6. undiagnosed vaginal bleeding
  7. uncontrolled htn
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6
Q

you use the CVD algorithm and find your patient has less than 5% 10-yr CVD risk. what can you give them in terms of estrogen therapy?

A

MHT ok for both!

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7
Q

you use the CVD algorithm and find your patient has a 5-10% 10-yr CVD risk. what can you give them in terms of estrogen therapy?

A

MHT ok, but use transdermal

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8
Q

you use the CVD algorithm and find your patient has a greater than 10% 10-yr CVD risk. what can you give them in terms of estrogen therapy?

A

none (avoid MHT!)

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9
Q

in addition to N, HA, bloating, bleeding and gallbladder dz, what are 3 big AEs of estrogen therapy?

A

stroke
DVT
breast cancer?

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10
Q

what should be added to estrogen treatment in women with uterus to minimize risk of endometrial hyperplasia/cancer?

A

progesterone

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11
Q

how many days per month should progesterone be taken with estrogen therapy?

A

12-14 days

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12
Q

in addition to N, HA, and bleeding, what are the AEs for progesterone (5)?

A
  1. weight gain
  2. irritability
  3. depression
  4. DVT
  5. decreased bone mineral density
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13
Q

what progesterone alternative can be used short term to treat symptoms during early menopause and is approved for hotflashes and osteoporosis prevention?

A

duavee (conjugated estrogens/bazedoxifene)

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14
Q

is estrogen +/- progestin protective or harmful against osteoporosis and fractures?

A

protective!

estrogen deficiency results in bone loss

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15
Q

HT long term risks? (4)

A
  1. VTE
  2. breast cancer
  3. heart disease ?
  4. dementia ??
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16
Q

HT long term benefits? (2)

A

osteoporosis

colon cancer ?

17
Q

when should you discontinue hormone therapy for post menopausal women?

A

typically 2-5 years

18
Q

what do all guidelines say about long term use of HT?

A

low dose of HT can continue in patients WITH symptoms

19
Q

what is the one drug approved for hypoactive sexual desire in women?

A

flibanserin

20
Q

what is a major contraindication of flibanserin? what happens?

A

alcohol

hypotension/syncope

21
Q

what are the two drugs approved for treating pain with intercourse?

A

ospemifene and prasterone

22
Q

what are the three types of estrogen in COCs?

A

ethinyl estradiol
mestranol
estradiol valerate

23
Q

what are the two types of progesterone in COCs?

A

norethindrone

levonorgestrel

24
Q

when are progestin-only pills typically used?

A

as an alternative for women unable to take estrogen-containing COCs
(can be used immediately post partum)

25
Q

what two medications require back up contraception while taking it?

A

griseofulvin (antifungal)

rifampin

26
Q

what BC exposes women to 60% more estrogen than women who take COCs and thus increases the risk of VTE

A

transdermal norelgestromin and ethinyl estradiol (Xulane)

27
Q

how often do you get the depo-provera shot?

A

q3 months (with 2 week grace period)

28
Q

what is the yuzpe method?

A

1 dose of 100mcg EE and 1 mg levonorgestrel followed by a 2nd dose of 100 mcg of EE and 1 mg levonorgestrel 12 hours later

29
Q

uncomplicated gonorrhea treatment of cervix, urethra, rectum, pharynx

A

1 dose ceftriaxone (IM)
PLUS
1 g azithromycin or doxycycline (BID x 7 days)

30
Q

are cephalosporins safe in pregnancy?

A

yeppers

31
Q

chlamydia treatment

A 
1 dose (1 g) azithromycin 
OR 
doxycycline (100mg BID x 7 days)
32
Q

what is recommended for pregnancy and chlamydia infxn?

A

azithromycin

33
Q

what is the response that the body has to penicillin when given for syphillis?
when does it present?

A

Jarisch-Herxheimer

2 hours - 24 hours

34
Q

can you use tetracyclines in pregnancy?

A

nope

Women's Health (3 decks)

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