Pharm- FC

Question 1

By which mechanism does NE increase preload?

Answer 1

vasoconstriction of splenic vein

Question 2

Which reaction in catecholamine synthesis pathway is rate limiting step? enzyme? cofactor?

Answer 2

tyrosine -> DOPA

tyrosine hydroxylase, BH4 is cofactor

Question 3

Which enzyme is primarily responsible for opiate metabolism?

Answer 3

UDP-glucuronosyltransferase

• opiate is renally excreted
  : phase 2 liver reaction, which yields very polar molecule

Question 4

Baby ate some pills from parents. brown-black emesis, abdominal pain, lethargy. What pill is this? how to treat it?

Answer 4

iron

deferoxamine

• key word for Iron poisoning; GASTRIC BLEEDING (or BROWN BLACK EMESIS), vomitting, nausea
• also question may say “candy” looking tablets, which is iron supplements

Question 5

What is function of β-arrestins?

Answer 5

physically block the receptor-Gs protein interaction, thereby preventing repeated and sustained activation of the Gs protein by the receptor.

=> regulation of beta adrenergic signaling

Question 6

Aspirin follows what order elimination?

Answer 6

zero order

: drug elimination rate is constant regardless of drug concentration