Pharm Exam 4 Flashcards

1
Q

Speed Shock

A

When a client receives an IV medication too rapidly, causing dizziness, chest tightness, and flushed face.

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2
Q

Extravasation

A

Causes pallor, swelling, and pain at IV site, which can extend tissue damage over time.

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3
Q

Anaphylactic shock

A

Causes bronchospasm, wheezing, SOB, severe hypotension, tachycardia, and respiratory or cardiac arrest.

The nurse should call the rapid response team and start oxygen if suspected.

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4
Q

Fluid overload

A

SOB, increased blood pressure, increases heart rate, increases respiratory rate, crackles in the lungs, neck vein distention, and edema

The nurse should prepare to administer a diuretic if suspected.

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5
Q

Phlebitis

A

the nurse should use a catheter with the smallest gauge possible to prevent irritation of the vein and phlebitis

the nurse should use a warm compress to treat phlebitis

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6
Q

0.9 % NaCl

A

Normal saline uses:
Increases intracellular fluid volume
Administration of blood transfusions
Replace fluid losses

Contraindications:
heart failure
pulmonary edema
renal failure
hypernatremia

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7
Q

Lactated Ringers (LR)

A

Contains electrolytes, sodium, chloride, potassium, calcium and lactate.

Uses:
provide fluid resuscitation
correct metabolic acidosis

Contraindications:
Heart failure
Renal failure,
head injury
liver disease
respiratory alkalosis

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8
Q

Infiltration

A

manifestations: pallor, swelling, and pain at the IV site

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9
Q

Extravasation

A

manifestations: blistering, tissue necrosis, ulceration

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10
Q

0.45% NaCl

A

Half normal saline

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11
Q

Isotonic

A

0.9 % Normal saline
Lactated ringers

Remains in the intravascular space

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12
Q

Hypertonic

A

3% saline

Pulls fluid out of the cells and into the veins

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13
Q

Hypotonic

A

0.45% half saline
0.18% saline
D5W - after metabolized

Moves fluid from the veins to the cells and interstitial spaces

Hemolysis can occur due to fluid moving from veins into cells.

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14
Q

Electron infusion devices (IV pumps)

A

deliver an accurate rate of fluid infusion

Pumps have a variety of safety features that protect the patient from an unwanted bolus, running dry, or running at an infusion rate inconsistent with the usual administration of the medication or fluid.

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15
Q

IV Pump Alarm detections

A

air in the tubing
volume is low
infusion is complete
low battery
occlusion

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16
Q

Using the piggyback method, where should the nurse place the secondary bag?

A

Higher than the primary bag

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17
Q

Bolus

A

Fluids or concentrated medication solution given by IV route over a relatively brief period of time. Equipment used to deliver varies, depending on existing IV lines, volume, and time to be infused.

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18
Q

Continuous IV Infusion

A

IV solution that flows continuously (until further notice) - typically seen in NPO and surgical patients

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19
Q

Drop Factor

A

Number of drops per milliliter (mL) delivered through various sizes of IV tubing. The tubing diameter affects the size of the drop. The DF is used to calculate flow rates on gravity administration sets.

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20
Q

Flow Rate

A

Rate at which fluid is delivered by IV infusion devices, in milliliters per hour (mL/hr).

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21
Q

Administration Set

A

another term for IV tubing;
may be used by gravity or IV pump

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22
Q

Infusion Line, Primary

A

Main IV line or lines connected to the patient.

The first one is usually “dedicated” to fluid delivery and maintenance. Additional primary and secondary lines are usually reserved for medications or medicated solutions that are incompatible with other fluids.

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23
Q

Infusion Line, Secondary

A

Tubing that connects to ports on the primary line and permits an additional medication or fluid to be added without disruption of the primary line.

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24
Q

IV Injection Ports

A

accessible port located on the IV line or IV solution container that permits access for injection of additional fluids or medications.

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25
Q

Intermittent Infusions

A

Usually small-volume infusions (up to 250 mL) of IV solutions with medication added delivered at intervals.

piggyback equipment, syringe pumps, and calibrated volume-control burette chambers.

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26
Q

IV Piggyback (IVPB)

A

Small-volume infusions, usually 50 to 250 mL, infused through a short secondary tubing line that is “piggybacked” to a port on a primary line.

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27
Q

IV Push

A

IV medication intermittent bolus dose of 1 to 50 mL, usually administered by manual direct injection with a syringe, sometimes via an infusion pump.

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28
Q

“Keep vein open” or “To keep open”;

A

flow rate order that may be given for a minimum rate that will keep the IV line patent and prevent coagulation.

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29
Q

Macrodrip

A

Gravity IV infusion tubing set that has a wide diameter to deliver large drops

common 10 drops per mL

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30
Q

Microdrip (pediatric tubing)

A

Gravity IV infusion tubing set that has a narrow diameter to deliver small drops and slower flow rates.

common 60 drops per mL

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31
Q

Osmolartiy, Tonicity

A

Solute concentration in solution.

The milliosmol (mOs) is the unit of measurement in plasma and is used as a basis for comparison with the contents of IV solutions.

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32
Q

Parenteral Fluids

A

Fluids administered outside of the digestive tract (e.g., IM, IV, subcutaneous).

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33
Q

Patency

A

State of being open and unblocked, such as a “patent IV site” or “patent airway.”

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34
Q

PCA Pump

A

Patient-controlled analgesia pump

An electronic IV pump with a syringe or IV bag programmed to dispense prescribed amounts of analgesic narcotics at prescribed intermittent intervals with lockout intervals.

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35
Q

Saline Lock

A

Resealable access device that permits additional IV lines or medications to be added into or on primary (main) IV tubing without initiating another injection site or disrupting the main IV line.

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36
Q

Volume-Control Burette Device

A

Transparent, calibrated small-volume container, with a capacity of 100 to 150 mL, that is manually connected to an IV line just below the main IV solution container.

protects at risk patients of overload by limiting the total amount of solution available in case of equipment or a rate failure incident.

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37
Q

Antibiotic

A

Having the ability to destroy or interfere with the development of a living organism. (antibacterial drugs)

38
Q

Antiseptic

A

One of two types of topical antimicrobial agents; a chemical that inhibits the growth and reproduction of microorganisms without necessarily killing them. (static agents)

39
Q

Bactericidal antibiotics

A

Antibiotics that kill bacteria.

40
Q

Bacteriostatic antibiotics

A

Antibiotics that do not actually kill bacteria but rather inhibit their growth

41
Q

Cross-reactivity

A

the potential to be allergic to a drug with a similar structure (for example, penicillins and cephalosporins

42
Q

Disinfectant

A

One of two types of topical antimicrobial agents; a chemical applied to nonliving objects to kill microorganisms.

43
Q

Glucose-6-phosphate dehydrogenase (G6PD) deficiency

A

An inherited disorder in which the red blood cells are partially or completely deficient in glucose-6-phosphate dehydrogenase, a critical enzyme in the metabolism of glucose. Certain medications can cause hemolytic anemia in patients with this disorder. This is an example of a host factor related to drug therapy.

44
Q

Empiric therapy

A

treatment before culture results - it involves the presumptive treatment of an infection to avoid treatment delay before specific culture information has been obtained

45
Q

Definitive therapy

A

antibiotic therapy after organism identified by cultures -
The administration of antibiotics based on known results of culture and sensitivity testing identifying the pathogen causing infection

46
Q

Host factors

A

Factors that are unique to a particular patient that affect the patient’s susceptibility to infection and response to various antibiotic drugs. Examples include a low neutrophil count or a lack of immunoglobulins in the blood that carry antibodies

47
Q

Prophylactic antibiotic therapy

A

Treatment to prevent an infection -Antibiotics taken before anticipated exposure to an infectious organism in an effort to prevent the development of infection.

48
Q

Slow acetylation

A

A common genetic host factor in which the rate of metabolism of certain drugs is reduced.

49
Q

sulfamethoxazole-trimethoprim (co-trimoxazole) - DOSAGE

A

It is available in both oral and injectable dosage forms.

50
Q

Subgroups of penicillin

A

natural penicillins - penicillin G, penicillin V

penicillinase-resistant penicillins - cloxacillin, dicloxacillin, nafcillin, oxacillin

aminopenicillins- amoxicillin, ampicillin

extended-spectrum penicillins - piperacillin, ticarcillin, carbenicillin, piperacillin/tazobactam

51
Q

Beta-lactamase

A

Any of a group of enzymes produced by bacteria that catalyze the chemical opening of the crucial beta-lactam ring structures in beta-lactam antibiotics.

52
Q

Beta-lactam

A

The designation for a broad class of antibiotics that includes four subclasses penicillins, cephalosporins, carbapenems, and monobactams

53
Q

beta-lactamase inhibitors

A

clavulanic acid (also called clavulanate), tazobactam, sulbactam, and avibactam

54
Q

Penicillin - mechanism of action

A

Penicillins bind to specific proteins called penicillin-binding proteins and inhibit peptidoglycan, which interfere with normal cell wall synthesis - eventually leading to lysis

55
Q

Penicillins - indications

A

Streptococcal infections (e.g. tonsillitis, pharyngitis, scarlet fever, endocarditis)

Sinus infections (often Augmentin)

56
Q

3rd Generation Cephalosporins - indications

A

weak against gram-positive bacteria but potent gram-negative antibiotics.

57
Q

Tetracyclines - indications

A

Wide spectrum gram negative and gram positive organism

Skin infections

Dental infections

Atypical infections (Rickettsia spp, Borrelia spp., Chlamydia spp., Mycoplasma pneumonia)

Lyme disease

acne

Adjunct treatment for protozoan infections

58
Q

Sulfonamides - indications

A

gram postive and gram negative

C. trachomatis

Nocardia

H. influenzae

UTIs (e.g. E. coli)

upper respiratory tract infection

staphylococcus infections because of the high rate of community- acquired MRSA infections

59
Q

Penicillins - adverse effects

A

Hypersensitivity: Anaphylaxis, rash, fever, wheezing
GI upset: Nausea, vomiting, diarrhea
Superinfections

60
Q

Penicillin - contraindications

A

Requires dosage reductions in renal impairment (piperacillin, ampicillin)

61
Q

Penicillin - nursing interventions

A

Screen clients with claimed allergies for true hypersensitivity reactions (e.g. rash, wheezing, anaphylaxis) ensuring the client did not just have an adverse effect (e.g. diarrhea, nausea, vomiting). Adverse effects do not result in a contraindication to this class of medications.

Monitor pulmonary function and for signs of allergic reaction.

Clients should be instructed to complete the full antibiotic regimen to encourage eradication of infection and discourage resistance.

Most penicillins can be taken with food to mitigate GI symptoms.

62
Q

Cephalosporins - Mechanism of action

A

Similar mechanism compared to penicillins – cephalosporins fall under the beta-lactam classification.

63
Q

Cephalosporins - Adverse effects

A

Hypersensitivity: Clients with true penicillin allergies develop reactions with cephalosporin usage. As cephalosporin generations increase the risk of allergic reactions to people with penicillin allergies decreases.

GI upset: Nausea, vomiting, diarrhea

CNS: Headache, dizziness

Nephrotoxicity

Superinfections

64
Q

Super infection

A

c.diff

secondary infection: candidiasis

when a patient doesn’t finish the full prescription, the infection comes back stronger

65
Q

Cephalosporins - interactions

A

Ceftriaxone should not be reconstituted or mixed with a calcium-containing product (e.g. Ringer’s or Hartmann’s solution) due to risk of precipitation in the lungs or kidneys

66
Q

Cephalosporins- nursing interventions

A

Screen for true penicillin allergies – ensuring a real hypersensitivity reaction.

Monitor pulmonary function and for signs of allergic reaction.

Generally safe in pregnancy.

Monitor renal function

Potential interaction with anticoagulants → bleed risk

IV and IM route only - ceftriaxone because of gi upset

once a day dosing

elimination is primarily in liver NOT kidneys

easily crosses the blood brain barrier so it can treat

give orally with food to decrease GI upset

Avoid use in clients taking anticoagulants

ANTABUSE - alcohol

Dont give with calcium - LR

67
Q

Tetracyclines - mechanism of action

A

Inhibit protein synthesis → inhibition of bacterial cell growth.

68
Q

Tetracyclines - adverse effects

A

Not pregnancy safe

Teeth discoloration

Sun sensitivity

Weakening of skeletal bone structure

Hepatotoxicity

Should not be given to kids <8 yrs old

Tooth discoloration

Fetal skeletal deformities if taken
during pregnancy

enterocolitis

gastric upset

vaginal candidiasis

Alteration in intestinal flora may
cause:

Superinfection (overgrowth of non-
susceptible organisms - Candida)

C. Diff infection

Maculopapular rash

69
Q

Tetracyclines - contraindications

A

Tetracyclines given to children under the age of 8 can cause permanent tooth discoloration if given for prolonged courses.

Accumulation of antibiotics can occur in fetal bone and teeth in pregnancy

Risk of hepatotoxicity in pregnant women

70
Q

Tetracyclines - nursing interventions

A

Obtain cutters before beginning antibiotic

Consult on increased sensitivity to light – avoid excessive sun exposure or use sunscreen

Avoid antacids and multivitamins with this medication

Interaction with birth control – caution with oral contraceptives; additional birth control may be needed

dairy products, antacids, and iron salts reduce oral absorption

Increase risk of digoxin toxicity- monitor digoxin levels

71
Q

Sulfonamides - contraindications

A

3rd trimester pregnancy

<2 YRS OLD

Risk of serious hypersensitivity reactions – screen for sulfa allergies

Blood dyscrasia – fatalities associated with severe reactions including agranulocytosis and aplastic anemia

Hepatic necrosis

Hyperkalemia – caution in clients with heart conditions

Hypoglycemia – caution in diabetics

Risk of thrombocytopenia

72
Q

Sulfonamides - nursing intervention

A

Screen for true sulfa allergies – monitor for signs and symptoms of hypersensitivity

Can take with food with upset stomach

Not safe for pregnancy

Nephrotoxic monitor for the following:
Scr > 1.3 = Bad for kidney

BUN > 20

Urine output < 30 ml/hr or less = kidney in distress

73
Q

Penicillin - interactions

A

NSAIDS

Oral contraceptives

Warfarin

74
Q

Sulfonamides - adverse effects

A

Hypersensitivity: Contraindicated when a known or suspected sulfa allergy is present (including allergies to sulfa containing drugs e.g. sulfonylureas, thiazides)

GI: Nausea, vomiting, diarrhea

Renal: Crystalluria

CNS: Headache, dizziness

Bone marrow depression

Photosensitivity, rash

75
Q

Bacteriostatic - mechanism of action

A

bind to calcium ions to form insoluble complexes

76
Q

The use of tetracycline is limited in children because of the occurrence of which side effect?

A

Discoloration of teeth

77
Q

Prophylactic Therapy

A

Administration of antibiotics prior to an anticipated exposure to infectious pathogens

78
Q

Definitive Therapy

A

Use of antibiotics based on known results of culture and sensitivity testing

79
Q

Empiric Therapy

A

Presumptive treatment of infection based on judgement of the pathogen(s) most likely causing an infection

80
Q

The nurse is reviewing the culture results of a patient with an infection, and notes that the culture indicates a gram-positive organism. Which generation of cephalosporin is most appropriate for this type of infection?

A

First-generation

81
Q

When reviewing the medication orders for a patient who is taking penicillin, the nurse notes that the patient is also taking the oral anticoagulant warfarin. What possible effect may occur as the result of an interaction between these drugs?

A

The penicillin will cause an enhanced anticoagulant effect of the warfarin.

82
Q

A patient tells the nurse that he is having nausea and decreased appetite during drug therapy with a tetracycline antibiotic. Which statement is the nurse’s best advice to the patient?

A

“Drink a full glass of water with each dose.”

-Oral doses should be given with at least 8 ounces of fluids and food to minimize gastrointestinal upset. Antacids and dairy products will bind with the tetracycline and make it inactive.

83
Q

A nurse is caring for a child who is allergic to penicillin. The nurse should verify which of the following prescriptions with the provider?

A

Piperacillin/tazobactam

84
Q

Which statement accurately reflects the method of action of penicillin?

A

Inhibition of bacterial cell wall synthesis

85
Q

A patient has a urinary tract infection. The nurse knows that which class of drugs is especially useful for such infections?

A

Sulfonamides

86
Q

The nurse is monitoring for therapeutic results of antibiotic therapy in a patient with an infection. Which laboratory value would indicate therapeutic effectiveness of this therapy?

A

Decreased white blood cell count

87
Q

Metronidazole - indications

A

Broad spectrum azole antibiotic

Primarily treats protozoal infections

Oral form treats bacterial and protozoal infections

Treats C.diff associated diarrhea which occurs secondary to broad-spectrum antibiotic use and bacterial vaginal infections

IV form helps to prevent anaerobic bacterial infections such as colorectal, abdominal, and vaginal surgeries.

Used in combination with other drugs to treat peptic ulcer disease.

88
Q

Metronidazole - mechanism of action

A

Bactericidal against anaerobic gram-negative bacteria and various types of Protozoa

Damages the DNA in anaerobic organisms

Unique because it doesn’t produce a pharmacological action until its inside the anaerobic organism

89
Q

Which antibiotics are NOT safe in pregnancy

A

Sulfonamides
Gentamicin
Tetracycline

90
Q

Vancomycin

A

PO,IV or rectal use

Ototoxity - especially in combination with gentamycin

Red man syndrome

Caution in renal impairment and hearing loss

91
Q

Aminoglycosides

A

E. Coli

Ototoxic

Nephrotoxicity

Intense neuromuscular blockade - respiratory depression and muscle weakness

Once a day dosing - trough level