Pharm Exam 3 Review Flashcards

1
Q

What are the combo hypertension medications?

A

ACEI/ ARB+ Thiazide
or
ACEI/ARB+ CCB

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2
Q

First line monotherapy for htn for african americans?

A

CCB or Thiazide

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3
Q

What are the benefits of aceis and arbs?

A

-decrease bp
-reduce plaque

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4
Q

What medications can increase HDL?

A

-statin
-niacin
fibrates

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5
Q

BP goal for most pts with htn?Who would this BP not apply to?

A

130/80
elderly

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6
Q

Initial txt for stage 1 HTN in a pt that does not have any risk factors (known ASCVD score)?

A

lifestyle modifications

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7
Q

Once pts with HTN have one risk factor start what?

A

monotherapy

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8
Q

What pts are higher risk of developing SAMS?

A

-Female
-low BMI
-older
-heavy exercise
-dehydration
-hypothyrodism
- renal dysfunction
- drug interactions

“tiny female marathon runner”

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9
Q

What would do for a pt with SAMS/

A

switch hydrophilic statin therapy
lower dose

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10
Q

medications that can cause 2ndry htn?

A

-NSAIDS
-ESTROGEN
-steroids
-antipsychotics
-atidepressants
-stimulants

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11
Q

What drug combos are the best at decreasing cardiovascular mortality rates?

A

acei or arb + ccb
or
acei or arb + thaizide

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11
Q

What is the first line treatment for htn?

A

acei, arb, ccb, thiazide/ diuretics

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12
Q

HTN emergency txt?

A

IV esmolol or nitroprusside or nicardipne or labetolo

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13
Q

Which pts do you want to rapidly decrease BP?

A

-aortic dissection
-hemorrhagic stroke
-preeclampsia
-pheochromocytoma

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14
Q

How long to decrease HTN emergency?

A

24-48 hrs

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15
Q

Stage 2 HTN txt?

A

depends if you need to decrase the SBP by 10 or 20.. determins mono or dual therapy

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16
Q

1st line pharm txt hypertriglyceridemia (<500)?

A

statins, lifestyle modifications

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17
Q

1st line txt for all HTN patients?

A
  • dash diet (most effective)
  • weight loss
  • mediterranean diet
  • aerobic activit (90-120 mins)
  • salt intake (<1200)
  • potassium intake (3500-5000)
  • reduce ETOH intake
  • DM management
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18
Q

HTN urgency?

A

180/120
w/o organ damage

19
Q

S/S of HTN emergency?

A

-hypertensice encephalopathy
-confusion
-acute kidney failure
-unstable angina
-dissecting aortic aneurysm
-intracranial hemorrhage

20
Q

At what age do you start screening for HTN?

A

18

21
Q

What HTN drugs can cause leukocyte reaction?

A

-hydralazine

22
Q

What agens are bile acid sequestrants?

A

-cholestyramine
-colestipol
-colesevelam

23
Q

why are bile acid sequestrants not used much?

A
  • constipation, GI upset
24
Q

Strategies ofr txt of HTN?

A

A, B, C chart

25
Q

Which thiazide is recommended as first line diuretic/ thiazide for HTN?

A

Chlorthiadone bc it showed some cardiovascular benefit

26
Q

Main reason clonidine is not frequently used?

A

Rebound HTN

27
Q

Which vasodilator cause cyanide poisoning? What influences this

A

Nitroprusside
duration and renal function

28
Q

First HTN drug for pts w/ HErEF?

A

Beta Blocker (metoprolol succinate, bispropolol, carvedilol)

29
Q

First line for pt w/ HTN and DM?

A

albumin - acei or arb
no albumin - any first line agent

29
Q

First line for HTN w/ CKD?

A

acei or arb

30
Q

what HTN drugs are safe in pregancy?

A
  • labetalol - first line
  • methyldopa
  • nifedipine
31
Q

First line HTN for BPH?

A

alpha blocker agonist

32
Q

First line monotherapy HTN for AA?

A

CCB or thiazide

33
Q

HTN urgency txt?

A

either increase dose of current med or if maxed out add oral captopril or clonidine

34
Q

What are the high intensity statins?

A

Rosuvastain - 20-40
Atorvastatin - 40-80

35
Q

What are they hydrophilic statins?

A

Rosuvatstin
pravastatin
fluvastatin

36
Q

Moderate intensity statins?

A

rosuvastatin 5-10
atorvastatin 10-20
simvastatin 20-40
pravastatin 40-80
lovastatin 40

37
Q

What is the txt for pts w/ NO hx of cardiovascular event with LDL of > 190?

A

high intensity statin

38
Q

What is the LDL goal for primary preventon for HLD pts?

A

LDL <100
50% reduction

39
Q

40-75 y/o pts w/o DM but have ASCVD > 20%?how about <20%?

A

high intensity statin
moderate intensity statin

40
Q

Primary prevention for ALL pts w/ DM regardless of HLD diagnosis?

A

moderate intensity statin

41
Q

Secoundary prevention (hx of cardiovascular events) txt?

A

high intensity statin

42
Q

Goal of LDL for secondary prevention?

A

LDL< 70

43
Q

What do you add if you max out of statin and still not at LDL goal?

A

add ezetimibe

44
Q

How often should cholestrol be checked on all HLD pts?

A

4-12 weeks