Pharm Exam 3

Question 1

What is MIC?

Answer 1

the minimum inhibitory concentration; used to determine the lowest concentration of antibiotic needed to inhibit growth

Question 2

What is MBC?

Answer 2

minimal bactericidal concentration; point at which everything is actually dead; in MIC shows bacteria that is just not growing; bacteria could still be in the tube; MBC is then taken to see if any bacteria still exists at all

Question 3

At the site of infection will the drug get where it needs to go?

Answer 3

BBB, eyes, testes, lungs, joints, skin (these all offer some protective barriers to antibiotics)

Question 4

What are some patient factors that affect antibiotics?

Answer 4

Immune system integrity
Renal function
Liver function
Circulation/perfusion- people with diabetes or CHF have trouble circulating 
Age
Pregnancy
Lactation
Integrity of the infection site (abscess, abrasion, inflammation)

Question 5

What are bactericidal drugs versus bacteriostatic drugs?

Answer 5

bactericidal= kill target organism, work independently from immune system, concentration dependent
bacteriostatic= stop growth and replication but do not kill bacteria, rely on patients immune system, they are time dependent

Question 6

What are cell wall inhibitors?

Answer 6

function to degrade peptidoglycan wall; they only function in actively proliferating cells

Question 7

What are drug classes that are considered cell wall inhibitors?

Answer 7

penicillin, cephalosporin, carbapenems, monobactams, beta-lactamase inhibitor combinations,