Pharm equations Flashcards
1
Q
How to determine Ke (elimination constant)?
A
Ke = Cl (clearance) / Vd
2
Q
How to determine Volume of distribution?
A
Vd = total drug / plasma concentration (C0)
3
Q
What are the two equations for determining half life t1/2?
A
t1/2 = 0.693 / Ke (elimination constant) t1/2 = 0.693 (Vd / Cl)
4
Q
How can you determine steady state concentration (Css)?
A
Css = Kin (drug input) / Cl (clearance)
5
Q
Maintenance dose =
A
M. D. = (dosing rate X interval) / f
6
Q
Loading dose =
A
L. D. = (Css x Vd) / f
7
Q
Bioavailability (f) =
A
f = AUC oral / AUC IV
