Pharm: Drugs Acting on the Central and PNS: Antiseizure, Antiparkinsonism, Muscle Relaxants, Opioids/Analgesic Agents, General/Local Anesthetic Agents Flashcards

1
Q

Drugs used to depress the CNS - prevents/reduces S & S of anxiety?

A

Anxiolytics

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2
Q

Former mainstay class for treatment of anxiety/for sedation/sleep induction (has many severe adverse effects and drug-drug interactions)?

A

Barbiturates

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3
Q

Class of drug acts on limbic system and reticular activating system to make GABA or gamma-aminobutyric acid (inhibitory neurotransmitter), more effective -> causing interference with neuron firing? (Depresses CNS block S&S of anxiety/cause sedation and hypnosis in higher doses)

A

Benzodiazepines

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4
Q

Ends in -LAM or -PAM?

A

Benzodiazepines used as anxiolytics-hypnotics

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5
Q

alprazolam, chlordiazepoxide, clonazepam, clorazepate, diazepam, estazolam, flurazepam, lorazepam, midazolam, oxazepam, quazepam, temazepam, and triazolam?

A

Benzodiazepines used as anxiolytics-hypnotics

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6
Q

pentobarbital, phenobarbital, secobarbital?

A

Barbiturates used as anxiolytics-hypnotics

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7
Q

Ends in -BARBITAL?

A

Barbiturates

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8
Q

AKA Xanax?

A

Alprazolam - anxiety, panic attacks -> make sure to taper

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9
Q

AKA Librium? Calms nervous system -> reduce risk of seizures, manages agitation, sootes anxiety

A

Chlordiazepoxide - anxiety, alcohol withdrawal, preop- anxiolytic

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10
Q

AKA Klonopin?

A

Clonazepam - panic disorders, restless leg syndrome, seizure disorders

Monitor for SI, liver function, taper after long term therapy

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11
Q

Different indication for clonazepam?

A

Restless leg syndrome

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12
Q

AKA Gen-Xene, Tranxene?

A

Clorazepate: Anxiety, alcohol withdrawal

Make sure to taper

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13
Q

AKA Valium?

A

Diazepam - anxiety, alcohol withdrawal, muscle relaxant, preoperative anxiolytic

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14
Q

Hypnotic, treatment for insomnia?

A

Estazolam, flurazepam

monitor liver/renal function, CBC if used long-term

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15
Q

AKA Ativan?

A

Lorazepam - anxiety, preanesthesia anxiolytic, insomnia d/t stress

Watch for sedation

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16
Q

AKA Midazolam?

A

Midazolam - sedation, anxiety, conscious sedation for short procedures ; continous sedation of intubated or mechanically ventilated patients

Keep resuscitation equipment close to help patient breathe PRN

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17
Q

Treatment for Anxiety disorders, alcohol withdrawal, hyperexcitability and agitation, and preoperative relief of anxiety and tension to aid in balanced anesthesia?

A

Benzodiazepines

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18
Q

Some adverse effects of benzos on the CNS/Peripheral?

A

Sedation, drowsiness, depression, lethargy, blurred vision, headaches, confusion, light-headedness

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19
Q

Monitor for dry mouth, N/V, constipation, inc liver enzymes; hypo/hypertension, arrhytmias, palpitations, urinary retention?

A

Adverse effects of benzos on GI, CV, and urinary systems

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20
Q

what to avoid when taking benzos?

A

CNS depressants - opioids and alcohol

DO NOT take with cimetidine, oral contraceptives, or disulfiram inc ben

Decreased when given with theophyllines

21
Q

AKA Butisol?

A

Butabarbital - short term sedative/hypnotic

Can produce aggressiveness/excitability

22
Q

AKA phenobarbital?

A

Phenobarbital - sedative-hypnotic, control of seizures, preanesthetic

Taper after long use; monitor injection sitess

23
Q

CNS depressants - inhibit neuronal impulse conduction in ascending RAS, depress cerebral cortex/alter cerebellar function; causes sedation, hypnosis, anesthesia?

A

Barbiturates

24
Q

What to watch out for in barbiturates?

A

CNS depression - drowsiness, solmnolence, lethargy, ataxia, vertigo

25
Q

Buspirone?

A

Treats anxiety - Causes dry mouth, headache -> caution in hepatic/renal impairment

26
Q

SEDATIVE: Dexmedetomidine?

A

Precedex - sedation for intubation/mechanically ventilated patients in ICU

1 mcg/kg IV over 10 min -> 0.2-0.7 mcg/kg/h w/ infusion device

27
Q

Diphenhydramine?

A

Benadryl: Sleep aid, motion sickness, allergies -> SHORT TERM treatment for insomnia

Monitor for drying effects -> thickened respiratory secretions

Breathing difficulties

28
Q

Eszopiclone?

A

Lunesta - Insomnia, 1 mg PO before bed

29
Q

Ramelteon?

A

Rozerem - treatment of insomnia characterized by difficulty falling asleep

Monitor for depression and SI

30
Q

Suvorexant?

A

Belsomra - treatment of insomnia w/ difficulty in sleep onset, and/or sleep maintenance

31
Q

Tasimelteon?

A

Hetlioz - treatment of non-24 hour sleep-wake disorder

32
Q

Zaleplon?

A

Sonata- short term treatment of insomnia

33
Q

Zolpidem?

A

Ambien, intermezzo, zolpimist - short term treatment of insomnia

34
Q

Can be sedating - used as preoperative medicines and postop to decrease need for narcotics?

A

Antihistamines: Promethazine (Promethegan), Diphenhydramine

35
Q

Buspirone?

A

Antianxiety, anticonvulsant, muscle-relaxant

Can reduce S&S of of anxiety w/o severe effects

36
Q

Amantadine, apomorphine, bromocriptine, carbidopa-levodopa, levodopa, pramipexole, rasgiline, ropinirole, rotigotine?

A

Dopaminergic agents

37
Q

Benztropine, diphenhydramine, trihexphenidyl?

A

Anticholinergic agents

38
Q

Entacapone, safinamide, selegline, tolcapone?

A

Adjunctive agents

39
Q

Includes lack of coordination, rhythmic tremors, rigidity/weakness, bradykinesia (extreme slowness)?

A

Characteristics of parkinsons

40
Q

Hallmark symptoms of parkinsonism?

A

Shuffling gait, drool, mask-like expression, difficulty swallowing

41
Q

What causes parkinsonism?

A

Loss of dopamine-secreting cells -> results in loss of inhibitory dopamine effect

42
Q

Amantadine?

A

Amantadine - Antiviral, treatment of idiopathic/drug-induced parkinsonism in adults

43
Q

Apomorphine?

A

Apokyn - intermittent treatment of hypomobility “off” episodes of parkinsonism

44
Q

Bromocriptine?

A

Parlodel - treatment of idiopathic parkinson dx -> beneficial after response to levodopa decreases

45
Q

Carbidopa-levodopa?

A

Sinemet - treatment of idiopathic Parkinson dx

46
Q

Levodopa?

A

Dopar - treatment of idiopathic Parkinson dx

47
Q
A
48
Q
A