Pharm Derm Exam 1 Flashcards
ABCDE
For Any Neoplasm
Asymmetry Borders Color Diameter Evolving / elevation
Types of benign tumors
Dermal tumors - acrochordon Cysts Vascular tumors (cherry hemangioma) Tumors of subcutaneous fat (lipoma) Hyperkeratotic reactions to chronic friction (callus/corn)
Premalignant neoplasms
Actinic keratosis appear over the exposed areas of the body as a result of actinic radiation
(solar)
Actinic Keratoses Treatments
Fluorouracil
imiquimod
ingenol mebutate
5 fluorouracil
Efudex (5%)
(Antimetabolite)
Cream or solution
a topical chemotherapy
most common treatment of most common precancer
(actinic keratoses)
Superficial basal cell carcinoma when conventional therapy is impractical
Preg Cat X
Adverse
Pain or burning at application site, pruritis, irritation, hyperpigmentation
5 fluorouracil MOA
Inhibits thymidylate synthetase and incorporates into DNA as an abnormal nucleotide
imiquimod
Aldara (5%) Cream
Actinic keratoses on face or scalp
Immune response modifier that is a Toll like receptor 7 agonist that activates immune cells
ingenol mebutate
Picato
Actinic Keratoses
Cell Death inducer
Actinic Keratoses Treatment options
Lesion directed
Surgery
Cryotherapy
Dermabrasion
Field directed Topical Fluorouracil imiquimod ingenol mebutate
or photodynamic therapy
Bowens disease Treatment
Surgical excision curettage electrodessication Photodynamic therapy Cryotherapy Topical fluorouracil Topical imiquimod
Keratoacanthomas
Conventional surgical excision is the treatment of choice for solitary Keratoacanthomas
Basal cell carcinoma topical treatment
Fluorouracil
imiquimod
Squamous cell carcinoma
If Low recurrence
Treatment
If low risk of recurrence Treatment Surgical excision Mohs surgery Curettage and electrodessication Cryotherapy Photodynamic therapy Radiation therapy (non surgical candidates)
pembrolizumab
Keytruda
Human programmed death receptor 1
PD -1 Blocking antibody
for unresectable metastatic melanoma
Embyro Fetal toxicity
pembrolizumab
MOA
releases the “brake” allowing T cells to act
protein receptor is the “brake”
pembrolizumab (keytruda)
Warnings and precautions
Immune mediated adverse reactions
Immune mediated adverse reactions
Pneumonitis, colitis, hepatitis, hypophysis, nephritis, hyperthyroidism, hypothyroidism
Administer corticosteroids based on severity of reaction
Withhold or discontinue keytruda depending upon severity of reaction
pembrolizumab (keytruda)
Warnings and precautions
Embryofetal toxicity
Keytruda may cause fetal harm
Advise females of reproductive potential to use highly effective birth control during treatment with keytruda and for 4 months after the last dose.
Acne treatments Based on MOA
Inflammation
Oral isotretinoin
Oral tetracycline
Topical retinoids
Azelaic Acid
Acne treatments Based on MOA
C. Acnes proliferation
Benzoyl peroxide
Topical and oral antibiotics
Azelaic acid
Acne treatments Based on MOA
Increased sebum production
Oral isotretinoin
Hormonal therapies
Acne treatments Based on MOA
Follicular Hyperproliferation and abnormal desquamation
Topical retinoids Oral Retinoids Azelaic acid Salicylic acid hormonal therapies
Retinoic acid
most common adverse effects
The most common adverse effects of topical retinoic acid are erythema and dryness that occur in the first few weeks of use
But these can be expected to resolve with continued therapy
Isotretinoin
Accutane
Sever recalcitrant nodular acne unresponsive to conventional therapy (eg. systemic ABX)
Not for children
Preg Cat X
Severe birth defects
Must register patients in Ipledge
Avoid tetracyclines (increased risk of pseudomotor cerebri)
Adverse
Dry skin, eyes, nose, mouth, lips
REMS
To inform patients about the serious risks associated with drug X
To minimize potential drug drug and disease drug interactions
To prevent the risk of fetal exposures to drug X
Isotretinoin (what is does)
Used for acne vulgaris
improve through reducing sebum production inhibiting growth of cutibacterium acnes and inhibiting comedogensis
Multiple side effects include
tetragenicity, mucocutaneous disorders, myalgia
Not for use with pregnancy
Not for use with tetracyclines
(Idiopathic intracranial hypertension (pseudo cerebri)
Oral ABX for acne
Tetra Doxy minocycline Sarecycline Erythromycin Bactrim Azithro
Topical combination Med
Benzoyl peroxide 5% / clindamycin 1%
Local ski irritation, may bleach skin or clothing
Hormonal agents for acne
Spironolactone
contraindicated in pregnancy
Azelaic acid
Azelex
Antibacterial / anti keratinizing agent
Sulfacetamide Topical 10%
Wash or lotion
Contra
sulfa allergy
Adverse
SJS
Erythema multiforme (HSV) (target lesions)
Folliculitis
Most common pathogen S. aureus
Other common pathogens Pseudo, malassezia, demodex mites
Mild s. aureus folliculitis usually resolves on its own
persistent S. aureus folliculitis = topical ABX
Topical mupirocin, clinda are preferred
Mupirocin MOA
inhibits bacterial protein synthesis by reversible binding and inhibiting isoleucyl transfer RNA synthetase
with subsequent inhibition of the incorporation of isoleucine into bacterial proteins
Brimonidine
Topical Mirvaso 0.33% gel
for persistent (non transient) facial erythema of rosacea
Pregnancy Cat B
Alpha 2 agonist (direct vasoconstriction of vessels)
Interactions
Caution with Beta blocker, antihypertensives and cardio glycosides
Topicals for rosacea
Topical Metronidazole
(metrogel, metrocream, metrolotion, noritate)
Topical doxy = Oracea
Topical Ivermectin = Soolantra
Topical azelaic acid = Finacea
Rosacea Patient Education
Avoidance of triggers of flushing
gentle skin care,
sun protection
Rosacea and tetracycline
Not to be used in children under nine
Erythema infectiosum
5th disease
There is no specific therapy and usually no indication for symptomatic treatment
Human parvovirus B19 infections
Hand foot and mouth Disease
clinical syndrome with
oral enanthem
macular, maculopapular, vesicular rash on
hands and feet
children and adults
coxsackie b
First seen in 1957 - toronto
Management is supportive
Measels
Prevention is key MMR vaccine
There is a role for Vitamin A
Supportive therapy includes antipyretics, fluids, treatment of bacterial super infections
(pneumonia, otitis)
When to use ribavirin in Measles
under 12
over 12 with pneumonia on vent
immuno suppressed patients
Alopecia areata
chronic, relapsing, immune mediated inflammatory disorder affecting hair follicle resulting in non scarring hair loss
Tx: topical, intralesional, systemic agents, devices
few clinical trials so response varies widely
Alopecia areata treatment
scalp intralesional injections of corticosteroids
topical corticosteroids in children or those unable to tolerate intralesional injection
with extensive alopecia areata or alopecia totalis who don’t respond to treatment
use topical immunotherapy
Number of potency categories of topical steroids
7
Group 1 is highest potency
Group 7 is lowest potency
(hydrocortisone 2%)
Topical steoirds in skin disease
anti inflammatory
anti mitotic
immunosuppressive
topical is safer than systemic
side effects can still occur especially with super potent
Side effects of higher potency topical corticosteroids
Cutaneous atrophy
telangiectasias
striae
others acneiform eruptions purpura hypopigmentation glaucoma
Onychomycosis causes
Dermatophytes
particular trichophyton rubrum is most common cause
Yeast (candida) and non dermatophyte molds can also cause onychomycosis