Pharm CNS Flashcards

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1
Q

bethanechol

A

cholinergic agonist (Rx urinary retention)

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2
Q

atropine

A

cholinergic antagonist (increase CO, decrease salivary secretions pre-op)

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3
Q

phenylephrine

A

A1 agonist (vasoconstrictor, mydriasis, nasal decongestant)

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4
Q

prazosin

A

A1 antagonist (Rx HTN)

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5
Q

clonidine

A

A2 agonist (Rx HTN ADHD)

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6
Q

dobutamine

A

B1 agonist (increases CO)

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7
Q

metroprolol

A

B1 antagonist (Rx HTN, angina, heart failure, post heart attack)

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8
Q

propranolol

A

nonspecific B antagonist (HTN, HA, tremors, heart)

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9
Q

terbutaline

A

B2 agonist (Rx asthma, lung constriction)

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10
Q

dopamine

A

PNS dopamine receptor agonist (low dose = urinary output, med = B1 and CO, high = A1 and ups BP

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11
Q

donepezil

A

anticholinesterase (Rx Alzheimer’s confusion or dementia)

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12
Q

succinylcholine

A

depolarizing NM blocker (muscle relaxant for procedures)

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13
Q

pancuronium

A

non-depolarizing NM blocker (muscle relaxant for procedures)

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14
Q

benztropine

A

anticholinergic (Rx PD)

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15
Q

pramipexole

A

dopa agonist (Rx PD)

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16
Q

carbidopa/levodopa

A

dopa precursor (Rx PD)

17
Q

selegiline

A

MAOB inhibitor (Rx PD)

18
Q

entacapone

A

COMT inhibitor (Rx PD)

19
Q

phenytoin

A

antiepileptic (epilepsy, all but absence, heart rhythm px)

-sxs CV/bradycardia, TENS, gingival hyperplasia, liver (AST, ALT), WBC suppression

20
Q

valproic acid

A

antiepileptic, GABA agonist

-sxs thrombocytopenia

21
Q

carbamazepine

A

antiepileptic (all but absence, Rx neuralgias)

-sxs BM suppression, ADH excretion so watch Na levels

22
Q

chlorpromazine

A

phenothiazine, FGA, dopa block only

-sxs EPS, inc prolactin, seizure risk, neuroleptic malignant syndrome NMS, HoTN, sedation

23
Q

clozapine

A

SGA atypical, block dopa and 5HT

-sxs metabolic syndrome = dyslipidemia, weight, DM, CV px, agranulocytosis, HoTN, sedation

24
Q

amitriptyline

A

tricyclic antidepressant, blocks reuptake of 5HT and NE

-sxs also blocks A1, NE, histamine, and cholinergic

25
Q

fluoxetine

A

SSRI 5HT only

-sxs bruxism, bleeders, EPS, serotonin syndrome, weight gain, 70% sexual dysfunction

26
Q

venlafaxine

A

SNRI 5HT and NE increase, some dopa

-does not block A1, histamine, or cholinergic

27
Q

phenelzine

A

MAOI MAOA/B inhibits breakdown of NE, Epi, dopa

-sxs hypertensive crisis from tyramine

28
Q

lithium

A

inhibits catecholamine response (BPD)

-sxs polyuria, renal px, hypoNa

29
Q

zolpidem

A

non-benzodiazepine potentiates GABA (sleep)

30
Q

lorazepam

A

benzodiazepine potentiates GABA (anxiety, seizures)