Pharm CNS

Question 1

bethanechol

Answer 1

cholinergic agonist (Rx urinary retention)

Question 2

atropine

Answer 2

cholinergic antagonist (increase CO, decrease salivary secretions pre-op)

Question 3

phenylephrine

Answer 3

A1 agonist (vasoconstrictor, mydriasis, nasal decongestant)

Question 4

prazosin

Answer 4

A1 antagonist (Rx HTN)

Question 5

clonidine

Answer 5

A2 agonist (Rx HTN ADHD)

Question 6

dobutamine

Answer 6

B1 agonist (increases CO)

Question 7

metroprolol

Answer 7

B1 antagonist (Rx HTN, angina, heart failure, post heart attack)

Question 8

propranolol

Answer 8

nonspecific B antagonist (HTN, HA, tremors, heart)

Question 9

terbutaline

Answer 9

B2 agonist (Rx asthma, lung constriction)

Question 10

dopamine

Answer 10

PNS dopamine receptor agonist (low dose = urinary output, med = B1 and CO, high = A1 and ups BP

Question 11

donepezil

Answer 11

anticholinesterase (Rx Alzheimer’s confusion or dementia)

Question 12

succinylcholine

Answer 12

depolarizing NM blocker (muscle relaxant for procedures)

Question 13

pancuronium

Answer 13

non-depolarizing NM blocker (muscle relaxant for procedures)

Question 14

benztropine

Answer 14

anticholinergic (Rx PD)

Question 15

pramipexole

Answer 15

dopa agonist (Rx PD)

Question 16

carbidopa/levodopa

Answer 16

dopa precursor (Rx PD)

Question 17

selegiline

Answer 17

MAOB inhibitor (Rx PD)

Question 18

entacapone

Answer 18

COMT inhibitor (Rx PD)

Question 19

phenytoin

Answer 19

antiepileptic (epilepsy, all but absence, heart rhythm px)

-sxs CV/bradycardia, TENS, gingival hyperplasia, liver (AST, ALT), WBC suppression

Question 20

valproic acid

Answer 20

antiepileptic, GABA agonist

-sxs thrombocytopenia

Question 21

carbamazepine

Answer 21

antiepileptic (all but absence, Rx neuralgias)

-sxs BM suppression, ADH excretion so watch Na levels

Question 22

chlorpromazine

Answer 22

phenothiazine, FGA, dopa block only

-sxs EPS, inc prolactin, seizure risk, neuroleptic malignant syndrome NMS, HoTN, sedation

Question 23

clozapine

Answer 23

SGA atypical, block dopa and 5HT

-sxs metabolic syndrome = dyslipidemia, weight, DM, CV px, agranulocytosis, HoTN, sedation

Question 24

amitriptyline

Answer 24

tricyclic antidepressant, blocks reuptake of 5HT and NE

-sxs also blocks A1, NE, histamine, and cholinergic

Question 25

fluoxetine

Answer 25

SSRI 5HT only

-sxs bruxism, bleeders, EPS, serotonin syndrome, weight gain, 70% sexual dysfunction

Question 26

venlafaxine

Answer 26

SNRI 5HT and NE increase, some dopa

-does not block A1, histamine, or cholinergic

Question 27

phenelzine

Answer 27

MAOI MAOA/B inhibits breakdown of NE, Epi, dopa

-sxs hypertensive crisis from tyramine

Question 28

lithium

Answer 28

inhibits catecholamine response (BPD)

-sxs polyuria, renal px, hypoNa

Question 29

zolpidem

Answer 29

non-benzodiazepine potentiates GABA (sleep)

Question 30

lorazepam

Answer 30

benzodiazepine potentiates GABA (anxiety, seizures)