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Pharm - Sam > pharm - cholinergic agonists > Flashcards

pharm - cholinergic agonists Flashcards

1
Q

Carbachol

A

direct cholinergic agonist - choline ester

for chronic open-angle glaucoma
produces miosis during ophthalmic surgery

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2
Q

Bethanchol

A

direct cholinergic agonist - choline ester

acts at muscarinic only
stimulates bladder w/o significant effects on HR or BP
tx: urinary retention post-op & post-partum

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3
Q

nicotine

A

direct cholinergic agonist - plant alkaloid

smoking cessation

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4
Q

Pilocarpine

A

direct cholinergic agonist - plant alkaloid
higher affinity for muscarinic receptor

tx: glaucoma
stimulates contraction of ciliary muscle fibers – which increases aqueous humor outflow – which decreases intraoccular pressure

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5
Q

cevimeline

A

direct cholinergic agonist - plant alkaloid

treats dry mouth (associated with Sjogren’s syndrome)

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6
Q

donepezil

A

reversible indirect cholinergic agnonist - cholinesterase inhibitor

tx. of alzheimer’s disease

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7
Q

edrophonium

A

reversible indirect cholinergic agonist - cholinesterase inhibitor

dx. of myasthenia gravis

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8
Q

neostigmine

A

reversible indirect cholinergic agonist - cholinesterase inhibitor

tx. of myasthenia gravis
antidote for skeletal muscle relaxants

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9
Q

pyridostigmine

A

reversible indirect cholinergic agonist -
cholinesterase inhibitor

tx. of myasthenia gravis

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10
Q

physostigmine

A

reversible indirect cholinergic agonist -
cholinesterase inhibitor

tx. overdose of anticholinergic drugs (ie. atropine, TCAs)

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11
Q

ecothiophate

A

irreversible indirect cholinergic agonist - cholinesterase inhibitor (ORGANOPHOSPHATE)

tx. of chronic refractory glaucoma

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12
Q

palathion

A

irreversible indirect cholinergic agonist - cholinesterase inhibitor (ORGANOPHOSPHATE)

pesticide

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13
Q

malathion

A

irreversible indirect cholinergic agonist - cholinesterase inhibitor (ORGANOPHOSPHATE)

pesticide

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14
Q

soman

A 
irreversibile indirect cholinergic agonist - 
cholinesterase inhibitor (ORGANOPHOSPHATE)

chemical warfare agent

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15
Q

how do you treat organophosphate poisoning?

A

maintain vitals and decontaminate

antidote:
atropine - to counteract ACh
pralidoxine - to regenerate cholinesterase

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Pharm - Sam (3 decks)

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