Pharm Cases from the Pharmacists

Question 1

aspirin

Answer 1

antiplatelet drug

Question 2

If aspirin is a weak acid, is it better absorbed in an acidic or basic environment?

Answer 2

acidic

Question 3

Should drugs absorbed in an acidic environment be given with a meal or on an empty stomach?

Answer 3

with a meal

Question 4

Average number of half lives to elimination

Answer 4

7 (or 5), play with the math

Question 5

Can you combine NSAIDs and steroids?

Answer 5

no you absolutely should not do that cause you increase risk for GI bleeding and perforation

Question 6

wash out period

Answer 6

time it takes for a drug to be completely eliminated in the system [in order to start another]

Question 7

What percent of mirtaz is eliminated in the feces vs urine?

Answer 7

~25% in feces, ~75% in urine

Question 8

Bioavailability

Answer 8

proportion of a drug dosed that enters the circulation

Question 9

dosing interval

Answer 9

time between doses

Question 10

Fentanyl

Answer 10

opioid analgesic with a very short half life that requires a loading dose to reach therapeutic concentrations

Question 11

Firocoxib (Previcox and Equioxx)

Answer 11

COX-2 NSAID for the control of pain and inflammation associated with OA in dogs and horses

Question 12

Cefovecin

Answer 12

aka Convenia, injectable antibiotic for a single SQ dosing

Question 13

Are protein bound drugs eliminated faster or slower?

Answer 13

slower

Question 14

THC is lipophilic. Will it be absorbed faster or slower when given with a meal?

Answer 14

faster

Question 15

ACE Inhibitors

Answer 15

commonly used drug in treatment of heart disease, hypertension, and proteinuric kidney disease

Question 16

Enalapril

Answer 16

ACE inhibitor 95% cleared by renal routes

Question 17

Benazepril

Answer 17

ACE inhibitor cleared by majority hepatic routes, but also renal or biliary (proportion depends on species)