Pharm C. 4, 5, 33, 34

Question 1

What the body does to the drug (ADME)

Answer 1

Pharmacokinetic phase

Question 2

During movement from administration into the systemic circulation

Answer 2

Absorption

Question 3

Drug movement from the systemic circulation to the site of drug action

Answer 3

Distribution

Question 4

Breaking down of drugs

Answer 4

Metabolism

Question 5

Drug removal from the body

Answer 5

Elimination

Question 6

Chemically converting a drug to a form that is more easily removed for. The body

Answer 6

Metabolism

Question 7

Drug metabolized in the body, reducing concentration of drug available before it reaches systemic circulation

Answer 7

First pass effect

Question 8

The amount of drug required to produce a therapeutic effect

Answer 8

Minimum effective concentration

Question 9

Level that results in serious adverse effects

Answer 9

Toxic concentration

Question 10

Plasma drug concentration between the minimum effective concentration and the toxic concentration

Answer 10

Therapeutic range

Question 11

The amount of time to produce a therapeutic effect

Answer 11

Onset of drug action

Question 12

When the medication has reached its highest concentration in the bloodstream

Answer 12

Peak plasma level

Question 13

Amount of time a drug maintains its therapeutic effect

Answer 13

Duration of drug action

Question 14

Higher amount of drug given 1 or 2 times to load the bloodstream with a sufficient level of drug. Given when therapeutic effects are needed quickly

Answer 14

Loading dose

Question 15

Keeps the plasma drug concentration in the therapeutic range

Answer 15

Maintenance dose

Question 16

What the drug does to the body

Answer 16

Pharmacodynamic phase

Question 17

A drug that if more powerful will produce a therapeutic effect at a lower dose

Answer 17

Potency

Question 18

A drug that produces the desired effect or intended result

Answer 18

Efficacy

Question 19

A drug that produces the same type of response as the endogenous substance is called

Answer 19

Agonist

Question 20

A drug that occupies a receptor and prevents the endogenous chemical from acting is called

Answer 20

Antagonist

Question 21

Examines the role of heredity in drug response

Answer 21

Pharmacogenetics

Question 22

Studies how all the genes can influence responses to drugs

Answer 22

Pharmacogenomics

Question 23

A nonspecific defense system if the body where damaging chemicals and microorganisms can be neutralized

Answer 23

Inflammation

Question 24

Cause vasodilation, relaxation of smooth muscle, increase capillary permeability, and sensitizes nerve cells to pain

Answer 24

Prostaglandins

Question 25

Key chemical mediator of inflammation that causes vasodilation, smooth muscle constriction, tissue swelling, itching (stored in mast cells)

Answer 25

Histamine

Question 26

Similar to H and contributes to symptoms of asthma and allergies (tighten airways and produce mucus)

Answer 26

Leukotrienes

Question 27

Similar to H, vasodilator, broken down and inactivated by angiotensin-converting enzyme (ACE)

Answer 27

Bradykinin

Question 28

At least 20 proteins combine in a cascade fashion to neutralize an antigen; simulates histamine release by mast cells. Also can be activated by incompatible blood transfusions

Answer 28

Complement

Question 29

Increase capillary permeability, attract WBC to site of inflammation, cause pain, induces fever

Answer 29

Prostaglandins