Pharm Block II - Vasodilators

Question 1

the 3 subclasses of Ca Channel blockers

Answer 1

1. Dihydropyrimidines (nifedipine)2. Phenylalkylamines (verpamil)3. Benzothiazepines (diltiazem)

Question 2

Calcium channel blockers general MOA

Answer 2

Works on vascular smooth muscle, cardia myocytes and SA/AV nodes to inhibit Ca influx

Question 3

Dihydropyridines prototype drug

Answer 3

Nifedipine

Question 4

Nifedipine MOA

Answer 4

Blocks Ca channels in vascular smooth muscle to prevent contraction; little effect on nodal tissue

Question 5

Nifedipine indications

Answer 5

HTN - long acting, not first line; Vasospastic - stable and unstable angina

Question 6

Nifedipine adverse effects

Answer 6

Heart palpitations, peripheral edema, headache, dizziness, fatigue

Question 7

Phenylalkylamine prototype drug

Answer 7

Verapamil

Question 8

Verapamil MOA

Answer 8

Inhibits Ca into vascular smooth muscle and nodal tissue

Question 9

Verapamil indications

Answer 9

Angina, HTN, arrythmias, (off label) migraines

Question 10

Verapamil adverse effects

Answer 10

Constipation, nausea, edema, dizziness, headache

Question 11

Benzothiazepines prototype drug

Answer 11

Diltiazem

Question 12

Diltiazem MOA

Answer 12

Inhibits Ca into vascular smooth muscle and nodal tissue; reduces afterload by dilating peripheral arteries; prolongs AV node refractory period

Question 13

Diltiazem indications

Answer 13

Vasospastic - stable and unstable angina; HTN; arrythmias

Question 14

Diltiazem adverse effects

Answer 14

Edema, headache, dizziness, nausea, rash, AV block

Question 15

Effect of nifedipine on arteries, coronary arteries, cardiac contractility, cardiac conduction

Answer 15

Arteries - dilate; coronary arteries - dilate; cardiac contractility - none; cardiac conduction - none

Question 16

Effect of verapamil on arteries, coronary arteries, cardiac contractility, cardiac conduction

Answer 16

Arteries - dilate; coronary arteries - dilate; cardiac contractility - decrease; cardiac conduction - decrease

Question 17

Effect of diltiazem on arteries, coronary arteries, cardiac contractility, cardiac conduction

Answer 17

Arteries - dilate; coronary arteries - dilate; cardiac contractility - decrease; cardiac conduction - decrease