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MHD/Pharm Block 4 > Pharm: All Cardio Drugs Combined > Flashcards

Pharm: All Cardio Drugs Combined Flashcards

1
Q

Heparin

A

MOA: Complex w/ ATIII to inactivate IIa and Xa, inhibit XI and XII, Releases TFPI; Indication: DVT, PE, Anticoagulation

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2
Q

LMW Heparin (Enoxaparin)

A

MOA: Complex w/ ATIII to inactivate IIa and Xa, inhibit XI and XII, Releases TFPI; Indication: DVT, PE, Anticoagulation

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3
Q

Fondaparinux

A

MOA: Complex w/ ATIII to inactivate IIa and Xa; Indication: DVT, PE

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4
Q

Argatroban

A

MOA: Directly inhibits IIa; Indication: Anticoagulation in HIT patients

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5
Q

Bivalirudin/Hirudin

A

MOA: Directly inhibits IIa; Indication: Anticoagulation in HIT patients

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6
Q

AT Concentrate

A

MOA: Directly inhibits IIa; Indication: DIC, sepsis, thrombophilia

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7
Q

Protamine Sulfate

A

MOA: Antagonizes Heparin; Indication: Heparin overdose

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8
Q

Warfarin

A

MOA: Antagonizes Vitamin K epoxide reductase, preventing activation of II, VII, IX, X.; Indication: DVT, Afib, Hypercoaguable state

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9
Q

Vitamin K

A

MOA: Cofactor in synthesis of active II, VII, IX, X; Indication: Warfarin Toxicity, Gastrinectomy, Hypoprothrombinemia

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10
Q

Apixaban, Rivaroxiban, Edoxiban

A

MOA: Direct inhibition of Xa; Indication: DVT, Afib, Hypercoaguable state

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11
Q

Dabigatran

A

MOA: Direct inhibition of IIa; Indication: DVT, Afib, Hypercoaguable state

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12
Q

Aspirin

A

MOA: COX inhibitor, lowering thromboxine and inhibiting platelet aggregation; Indication: ACS, stroke, arterial thrombosis

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13
Q

Clopidogrel, Ticagrelor, Prasurgrel

A

MOA: ADP receptor inhibitor (prodrugs); Indication: ACS, stroke, arterial thrombosis

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14
Q

Kangrelor

A

MOA: ADP receptor inhibitor (no activation required); Indication: ACS, stroke, arterial thrombosis

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15
Q

Dipyridamole

A

MOA: Phosphodiesterase inhibitor (prevents platelet activation); Indication: Arterial Thrombosis, stroke

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16
Q

Cilostazol

A

MOA: Phosphodiesterase inhibitor (vasodilation); Indication: Intermittent Claudication

17
Q

Abciximab, Eptifibatide, Tirofiban

A

MOA: GPIIb/GPIIIa inhibitors; Indication: ACS, PCI, MI

18
Q

Fish Oil

A

MOA: Competitive inhibitor of prostaglandin pathway, preventing platelet activation; Indication: Thrombosis Prophylaxis

19
Q

Zileuton, Montelkast, Zarirlkast

A

MOA: Leukotriene Pathway inhibitors; Indication: Asthma

20
Q

Streptokinase/Urokinase

A

MOA: Activates Plasminogen to Plasmin, Fibronlysis; Indication: Thombosis, MI, Stroke, PE

21
Q

tPA

A

MOA: Activates Plasminogen to Plasmin, Fibronlysis; Indication: Thombosis, MI, Stroke, PE

22
Q

Epsilon Amino Caproic Acid and Tranexemic Acid

A

MOA: Inactivation of tPA; Indication: tPA overdose, Excessive bleeding

23
Q

Statins

A

MOA: HMG-CoA reducatse inhibitor -> decreases Cholesterol Synthesis, activating SREBP transcription factor, increasing LDLR synthesis, increasing cholesterol clearance in bile; Indication: Hyperlipidemia, High LDL

24
Q

Cholestryramine, Colestpol, Colesevelam

A

MOA: Binds Bile Acids in small intestine and causes excretion. This activates Cholesterol 7a-Hydroxylase, which uses cholesterol to synthesize more bile acids. Also increases SREBP TF and LDLR.; Indication: Hyperlipidemia, High LDL

25
Q

Ezetimibe

A

MOA: Inhibits Cholesterol absorbtion at intesting (via NPCL1); Indication: Hyperlipidemia, High LDL

26
Q

Niacin

A

MOA: Many actions, decreases VLDL synthesis and increases VLDL clearance, while also decreasing LPa(homologue of plasminogen, which competes for tPA), resulting in decreased thrombosis; Indication: High Triglycerides, High LDL, Low HDL

27
Q

Gemfibrozil and Fenofibrate

A

MOA: Ligand for PPAR Transcription factor, decreasing ApoC3 synthesis (less VLDL production) and increasing LPL synthese, increasing TG breakfown in VLDL to increase VLDL clearance; Indication: High Triglycerides, Low HDL

28
Q

Alirocumab and Evolocumab

A

MOA: Inhibit PCSK9, resulting in increased recycling of LDL receptors to hepatocyte membranes; Indication: High LDL uncontolled by max statins, Heterozygous FH

29
Q

Lomitapide

A

MOA: Inhibition of MTP to decrease lipoprotein production; Indication: Homozygous FH

30
Q

Mipomersen

A

MOA: Antisense mRNA decreasing ApoB100 and ApoB48 production, decreasing Lupoprotein production; Indication: Homozygous FH

MHD/Pharm Block 4 (25 decks)

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