Pharm

Question 1

How much Bicitra is needed to buffer acid?

Answer 1

30 ml

Question 2

PPI inhibt____, _____, and ____.

Answer 2

gastrin, Ach, histamine

Question 3

PPI are ____that require acid to activate

Answer 3

prodrugs

Question 4

T/F No dose adjustment need to made with PPI’s on renal, hepatic and elderly pt’s.

Answer 4

T

Question 5

What conditions delay gastric emptying?

Answer 5

Trauma, pregnancy, DM, opioids, pain, anxiety

Question 6

What makes Reglan a prokinetic?

Answer 6

It makes the GI tissue more sensitive to Ach which besides motility it also increases LES

Question 7

Why is Reglan an antiemetic?

Answer 7

The D2 and 5HT3 antagonism.

Question 8

What is the black box warning with reglan?

Answer 8

Tardative Dyskenisia

Question 9

A low/high dose of Reglan is needed to be used for PONV but with this dose it causes EPS symptoms.

Answer 9

high. If you use it, it still reduces R by 30-40%

Question 10

Octreotide is a G ___ linked which increases __ and ___.

Answer 10

Gq; phospholipase C and IP3

Question 11

Carcinoid tumors are typically located in ____. They cause s/s of ______.

Answer 11

GI tract, flushind, diarrhea, increase temp, decrease BP

Question 12

Butyrephones are??? What SE do they have?

Answer 12

Dopamine receptors antagonist that come with too many SE (diarrhea, EPS, and sedation) so not used as much

Question 13

What are some EPS symptoms?

Answer 13

–	Akathisia (restlessness)
–	Tardive dyskinesia (irregular, jerky movements)
–	Bradykinesia (slow movements)
–	Dystonia (spasms)
–	Parkinsonism (rigidity)

Question 14

Prochlrperzine is a strong ___ but also a fairly ____ and ____.

Answer 14

D2, antimuscurinic, and antihistamine

Question 15

What receptors are in the CTZ?

Answer 15

NK1, Opioids, D2, 5HT3

Question 16

What receptors are in the GI?

Answer 16

NK1, 5HT3

Question 17

What are the receptors in the vestibular?

Answer 17

H2, Ach

Question 18

How do anticholinergics cause a decrease in PONV?

Answer 18

by reducing the excitability of the labyrinth receptors thus depressing conduction via the vestibular cerebellar pathways. It corrects the imbalance of ACh in the CNS

Question 19

Antihistamines are primarily _____ but also slight _____ and ____.

Answer 19

H2; muscurinic and D2.

Question 20

What are some overall SE of antihistamine?

Answer 20

dry mouth, urinary retention, EPS

Question 21

How do benzos help in PONV?

Answer 21

They decrease secretions by controlling anxiety which causes secretions.

Question 22

Ginger increases ____ so it is bad to use in ___ patients.

Answer 22

bile; GB

Question 23

Ginger also inhibits _____, increasing _____ risk. So stop it ___before sx. Anything above _____ is TOXIC.

Answer 23

platelet aggregation; bleeding; 2 weeks; 2mg/kg/day