Pharm 9 Flashcards
1
Q
What are the reactions in phase I metabolism? Are the drugs still active?
A
1) Hydrolysis, Oxidation, Reduction –> slighty hydrophilic
2) Often, sometimes even more toxic
2
Q
What are the three actions of the peroxisome?
A
1) B-oxidation
2) Myelin synthesis
3) Alcohol metabolism
3
Q
What are the reactions in phase II metabolism? Are the drugs active?
A
1) GAS Glucuronidation, Acetylation, and Sulfonation –> highly hydrophilic
2) Usually inactive
4
Q
What is the clinical use of Fomepizole?
A
Methanol/Ethylyne Glycol poisoning due to its inhibition of alcohol dehydrogenase
5
Q
What is the mnemonic for CYP inducers?
A
Guinness, Coronas, and PBRS induce Chronic alcoholism Griseofulvin Carbamazapine Phenytoin Barbituates Rifampin St. John's
6
Q
What is the mnemonic for CYP inhibitors?
A
CRACK AMIGOS Cimetidine Ritonavir Amiodarone Cipro Ketoconazole Acute Alcohol Macrolides Isoniazid Grapefruit juice Omeprazole Sulfonamides
7
Q
What are dietary restrictions with metronidazole?
A
Avoid alcohol due to disulferam-like affects
