Pharm

Question 1

chemotherapeutic agents for breast cancer

Answer 1

Cyclophosphamide
Methotrexate
5-FU

Question 2

tamoxifen

Answer 2

selective estrogen receptor modulators

Question 3

AML Tx

Answer 3

7+3 (7 days of cytarabine (cytosine arabinoside), and 3 days daunorubicin)

Question 4

best drug for nausea and vomiting**

Answer 4

dexamethasone (Decadron)

ondansetron (Zofran) also works well - 5-HT3 recep antag

Question 5

most commonly used chemotherapeutic agent for colon ca**

Answer 5

Antimetabolites (5-flourouracil)**

Question 6

adjuvant Tx for gastric ca**

Answer 6

Gleevec – 54% partial response
Extremely helpful in Locally invasive tumor
5 year survival 48%, recurrence 1st 2 years

Question 7

epidermal growth factor receptor (EGFR)*

Answer 7

tumor marker currently studied as targeted therapy
mutation can cause lung ca in non-smokers
predominant in adenocarcinoma

Question 8

CML Tx

Answer 8

TKI: disease control, eg Gleevec (imatinib, Spyrcel, Taiga, Bosulif) - only affects ca cells, NOT cure
potential cure w/ allo hematopoietic transplant

Question 9

Philadelphia neg ALL/LBL Tx adult

Answer 9

Hyper CVAD (cytoxan vincristine, daunorubicin, dexamethasone, alternating with methotrexate, cytarabine), nasty tx
Tx CNS w/methotrexate and cytarabine
G-CSF daily injection

Question 10

Philadelphia pos* ALL/LBL adult tx*

Answer 10

add TKI*

Question 11

CLL Tx

Answer 11

depends on indolent or active progression
cannot be cured
radiation therapy if localized
no single agreed upon Tx
70-95% CR (complete remission) rate with Fludarabine, cyclophosphamide, rituximab/Rituxan
and ibrutinib/Imbruvica

Question 12

Tx of Hairy cell leukemia

Answer 12

no cure, observe initially
Chemo with cladribine (preferred) or pentostatin
interferon alfa if severe

Question 13

NHL ChemotherapyIndolent lymphomas*

Answer 13

CHOP or R-CHOP*** (rituximab/Rituxan, Cyclophosphamide, doxorubicin, vincristine, prednisone)

Question 14

NHL ChemotherapyAggressive Lymphomas

Answer 14

R-CHOP (FIRST LINE) rituximab, cyclophosphamide, doxorubicin, vincristine & prednisone
First line treatment for Activated B cell DLBCL: R-CHOP plus lenalidomide or ibrutinib or bortezomib
GAZYVA/(Obinutuzumab): showing better results than Rituxan
Tx targets CD20 B lymph antigen

Question 15

Hodgkin Lymphoma Tx

Answer 15

-Radiation therapy (stage I & II and some stage IIIa)ABVD (doxorubicin, bleomycin, vinblastine, decarbazine)
-Chemo for stage III b and IV
ABVD* (BIG DRUG THAT IS USED)
FAVORABLE PROGNOSIS; more relapse in stage 3,4

Question 16

Tx of multiple myeloma

Answer 16

if “smoldering”, observe
normally, immediate tx required or die in 6mon**
eval for transplantation
3 drug regime: Bortezomib/Velcade, plus Lenalidomide/Revlimid plus dexamethasone/Decadron (VRd)