Pharm

Question 1

Drug A ED50 10mg Drug B 100mg

Answer 1

Drug A 10x more potent

Question 2

Alcohol and red flush

Answer 2

Pleomorphism ALDH2

Question 3

Colonisation
Infection
Bactereamia
Sepsis
Septiceamia

Answer 3

Presence of Bacteria
Multiply and invade
in Blood
Organ
Systemic infection

Question 4

Symporter Kidney

Answer 4

Na+/Cl-

Question 5

Plasma Concentration increases by

Answer 5

Clearance and Bioavailability

Question 6

t1/2

Answer 6

5x t1/2 to get to steady state

Question 7

Loading Dose calculated

Answer 7

Css x Vol Distrubution

Question 8

Increase absorption of Paracetamol

Answer 8

Metoclopramide

Question 9

Toxicity of Paracetamol

Answer 9

CYP450 - CYP2E1 - (Sulphotransferase?)

Question 10

Increases toxicity

Answer 10

Grapefruit

Question 11

St Johns Wart

Answer 11

Enzyme inducer of metabolism ( increase conc- in blood)

Question 12

What decreases absorption

Answer 12

Milk

Iron

Question 13

CYP450

Answer 13

Enzyme inhibitor

Question 14

Enzyme Inhibitor

Answer 14

CYP450

Question 15

What increases bioavailability of morphine

Answer 15

Cirrhosis

Question 16

Adverse Reactions

Answer 16

Type A: Increase effect/Exagg
Type B: Bizzare
Type C: Long Term (addiction/withdraw)
Type D: Delayed (Feotus)
Other: Unavoidable (Chemo)

Question 17

G Coupling protein receptor

Answer 17

Opiods -Morphine - mins

Question 18

Glucocorticoid Receptor

Answer 18

Intracellular - Prednisone and Betamethasone

Question 19

Availability

Answer 19

Unscheduled (supermarket), 
Pharmacy (otc), 
Pharmacist (Dent), 
S4 (Perscirption)
S8 (Controlled addiction)
S9 (prohibited)

Question 20

What is a prodrug

Answer 20

Morphine - codeine

Question 21

Antifungal Instruction

Answer 21

1 week after resolved to remove pores

Question 22

What drug causes Gingival Hyperplasia

Answer 22

Phenytoin

Question 23

What do you have to be careful of Alendronale

Answer 23

Bisphosphonate - Osteonecrosis

Question 24

What drug to avoid if allergic to penicillin

Answer 24

Cephalexin

Question 25

What to remember for Angina med Glyceryl Trinitrate

Answer 25

Dissolve under the tongue - avoid first pass

Question 26

What is the Paraenteral route of administration

Answer 26

IV

Question 27

Metabolism of Drugs

Answer 27

Sulphotransferase

Question 28

Hypertensive (ACEI), Diuretic and NSAIDs

Answer 28

ACEI= Vasodilate efferent arteriole = decreases GFR
Diurestics = Decrease Plasma Vol = Decrease Renal Flow
NSAIDs=decrease prostaglandins = vasoconstrict Afferent renal arteriole = cant regulate GFR = retains fluid = decrease effect of ACEI and decrease Renal Function
= ACUTE RENAL FAILURE

Question 29

Increase bleeding warfrin and Aspirin

Answer 29

Pharmacodynamic
warfrin decreases synthesis vit K dependant coagulation factor =
Aspirin irreverably bond to cyclooxgenase = decrease thromboxan = both anti-coagulant pathway

Question 30

Increase bleeding warfrin and Ibuprofin

Answer 30

Pharmacodynamic
warfin decreases synthesis vit k dependant coagulation factor
Ibu= anti-platelet - sim to aspirin

Question 31

Failure of Antifungal by taking Antacid

Answer 31

Pharmacokinetic

antacid blocks aborpsion = no drug in B = no effect

Question 32

Increase sedation Codeine and Alcohol

Answer 32

Pharmacodynamic

CNS

Question 33

Digoxin (hypertensive) and iburprofin

Answer 33

Pharmacokinetic
Ibu =enzyme inhibitor = cycloxgenase = decrease prostaglandin = decease BF in renal = decrease renal Cl digoxin = increase Blood conc- = toxicity
diagoxin narrow TI

Question 34

Increased in xerostomia

Answer 34

Pharmacodynamic

amitriptyline and ipratropium (asthma)

Question 35

Doxycycline and antiacid

Answer 35

Pharmacokinetics

antacid increase Ph of stomach - effects abs

Question 36

increased sedation codeine and Tamazepan

Answer 36

Pharmacodynamic
Tamazapan depress cns
Increase affinity of neurotransmitter gaba

Question 37

old pt on amitriptyline (anti-depressant) and diazepam sedation)

Answer 37

Pharmacodynamic

increased drowziness