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Pharm > Pharm > Flashcards

Pharm Flashcards

1
Q

Adverse effects of Doxorubicin

A

Cardiotoxicity

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2
Q

Adverse effects of Cyclophosphamide

A

Hemorrhagic cystitis

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3
Q

Adverse effects of Bleomycin

A

Pulmonary fibrosis

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4
Q

Adverse effects of Vincristine and Paclitaxel

A

Peripheral neuropathy

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5
Q

What is used to manage chemotherapy-induces emesis?

A

5HT3 receptor blockers and NK-1 inhibitors

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6
Q

What is used to prevent and treat chemotherapy induced neutropenia?

A

Filgrastim and Sargramostim

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7
Q

Used to rescue bone marrow from methotrexate?

A

Leucovorin

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8
Q

Used to reduce anthracycline-induced cardiotoxicity?

A

Dexrazoxane

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9
Q

Reduces renal toxicity caused by cisplatin?

A

Amifostine

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10
Q

What are the adverse effects of methotrexate?

A 
Common: stomatitis, mucositis, myelosuppression, alopecia, nausea, vomiting 
Renal Damage
Hepatic fibrosis and cirrhosis 
Pneumonitis
Neurologic Toxicities
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11
Q

What is the mechanism of Leucovorin?

A

It bypasses the inhibition of methotrexate providing N5, N10-methylene-THF for normal tissue

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Pharm (14 decks)

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