pharm Flashcards
Mitoxantrone
Anthracycline that binds DNA and causes strand breakage
Toxicity: blue sclera and fingernails
Mitomycin C
Antibiotic that is a potent DNA linker through alkylation, active in all phases of cell cycle
Toxicity: HUS, nausea, vomitting
Activated via reduction –> act on tumor cells in hypoxic environment
Oxaliplatin
platinum based alkylating agent; same MOA as cisplatin and carboplatin
major toxicity=laryngo-pharyngeal dysesthesia
Bortezomib
Proteosome inhibitor used to arrest cell in G2-M
Used for multiple myeloma
Dasatinib
tyrosine kinase inhibitor used to overcome imatinib resistance
same mechanism as imatinib
Nivolumab
Monoclonal antibody that serves as PD-11 inhibitor to prevent programmed cell death
Used with BRAF V600
SE: immune-mediated penumonitis, colitis, hepatitis, endocrinopathies
Procarbazine
Non-classic alkylating agent that acts as a monoamine oxidase inhibitor
Oral
Hydroxyurea
Inhibits ribonucleoside reductase
S-phase specific
used for S-S disease to increase
HbF
Crizotinib
Inhibits ALK, ROS, HGFR, and other TKs
NSCLC - Younger, non-smokers, WT for EGFR and RAS
ATRA
PML-RAR fusion protein, leads to differentiation and death of APML cells
Used for Acute promyelocytic leukemia (APML)
Toxicity: Leukocytosis
Capillary leak syndrome (pulmonary edema), renal failure
Occurring shortly after initiation of ATRA therapy
Lenolidamide
Immune modulator used for multiple myeloma
NK cell dependent cytotoxicity
Nivolumab
PD-1 inhibitor – binds to programmed cell death receptor, which inhibits T cell death (reverses T cell suppression and induces antitumor response)
toxicity: Immune-mediated pneumonitis, colitits, hepatitis, endocrinopathies; fatigue, rash, MSK pain, pruritis
Pharm causes of aplastic anemia
Chloramphenicol Sulfonamides Benzene Alkylating agents Antimetabolites
