Pharm

Question 1

The lipoxygenase pathway produces what two groups of eicosanoids?

Answer 1

Leukotrienes and Lipoxins

Question 2

The cyclooxygenase pathway produces what 3 main groups of eicosanoids?

Answer 2

Prostaglandins, Prostacyclins, and Thromboxanes

Question 3

What eiconsanoid is secreted mainly from platelets?

Answer 3

TXA2

Question 4

What eicosanoid is secreted mainly from endothelial and vascular smooth muscle?

Answer 4

PGI2

Question 5

What two eicosanoids are secreted mainly by mast cells and WBC’s and play a role in inflammation?

Answer 5

Leukotrienes and Lipoxins

Question 6

What eicosanoid could be found in airway epithelial cells?

Answer 6

Leukotrienes

Question 7

Which COX is found in endothelial cells?

Answer 7

COX1

Question 8

Which COX is found in connective tissue?

Answer 8

COX2

Question 9

What are 3 eicosanoids responsible for dilation of vascular smooth muscle?

Answer 9

PGE2
PGI2
PGF2a (arterioles only)

Question 10

What 2 eicosanoids act as potent vasocontrictors?

Answer 10

TXA2

PGF2a (superficial veins only)

Question 11

What is a leukotriene that is responsible for vascular permeability and plays a role in inflammation?

Answer 11

LTB4

Question 12

Eicosanoid responsible for bronchial smooth muscle contraction

Answer 12

PGF

Question 13

Eicosanoid responsible for bronchial smooth muscle relaxation

Answer 13

PGE

Question 14

2 leukotrienes involved in asthma and respiratory analphylaxis and makes up the SRS-A (slow-reacting substance of anaphylaxis)?

Answer 14

LTC4 and LTD4

Question 15

What main leukotriene is responsible for bronchoconstriction?

Answer 15

LTB4 –> leukotrienes in genereal

Question 16

What 2 eicosanoids are responsible for uterine contraction in PREGNANT women?

Answer 16

PGE2 and PGF2a

Question 17

What 2 eicosanoids are responsible for uterine contraction and relaxation in NON-pregnant women respectively?

Answer 17

PGF2a (contraction)

PGE2 (relaxation)

Question 18

What 3 eicosanoids are potent GI stimulators?

Answer 18

PGE2
PGF2a
LTB4

Question 19

What 2 eicosanoids inhibit platelet aggregation?

Answer 19

PGE2 and PGI2 (also inhibit histamine)

Question 20

What eicosanoids would you give a pregnany woman to induce labor?

Answer 20

PGF2a

PGE2

Question 21

A patient has patent ductus arteriosus and needs to maintain patency during surgery. What eicosanoid would you give to maintain this?

Answer 21

PGE1

Question 22

What 2 eicosanoids inhibit acid and pepsinogen secretion in the stomach?

Answer 22

PGE2 and PGI2

Question 23

A patient is suffering from peptic ulcers and is given a eicosanoid to reduce the amount of acid secreted, what eicosanoid was given?

Answer 23

PGE1

Question 24

A patient is suffering from Erectile Dysfunction and elects to receive injections of an eicosanoid directly into the corpus cavernosum, what eicosanoid was given?

Answer 24

PGE1

Question 25

A patient suffering from arthritis will have marked levels of these 2 autocoids

Answer 25

COX2

PGE2 (pain)

Question 26

These 4 autocoids are seen in elevated levels in asthma patients

Answer 26

PGD2
LTB4
LTC4 & LTD4 (anaphylaxis related)

Question 27

Patients suffering from Crohn’s and Ulcerative colitis have elevated levels of this autocoid due to inflammation

Answer 27

LTB4 (WBC chemotaxis)

Question 28

These 2 autocoids are seen in elevated levels in patients suffering from dysmenorrhea

Answer 28

PGF2a

PGE2 (pain)

Question 29

Patients develop glomerulonephritis because of elevated levels of this autocoid due to complement protein activation

Answer 29

LTB4

Question 30

A form of glomerulonephritis, caused by these leukotrienes, where blood flow through the glomerulus has been equilized which decreases the glomerular filtration rate.

Answer 30

Cysteinyl leukotrienes:

LTC4, LTD4, LTE4, and LTF4