Pharm 5 Androgens Flashcards
1
Q
Primary stimulator of testosterone synthesis and androgen-binding globulin
A
LH - testosterone (leydig cells)
FSH - ABG
2
Q
LH, FSH stimulated by
A
GnRH (pulsatile)
3
Q
LH, FSH inhibitors (male)
A
Testosterone, Estradiol
4
Q
Site of female androgen synthesis
A
Corpus luteum
5
Q
Testosterone metabolism
A
5a-reductase -> dihydrotestosterone P450 aromatase (CYP19) -> estradiol
6
Q
5a reductase & CYP19 locations
A
5a reductase - Skin, bone, liver, genitals
CYP19 aromatase - Fat, liver, bone
7
Q
Testosterone action
A
A-R ->
- Internal genitalia (Wolffian development)
- Skeletal muscle (puberty)
- Erythropoiesis
8
Q
Dihydrotestosterone action
A
A-R ->
- Eternal genitalia (differentiation and maturation)
- Hair follicles (puberty)
9
Q
Estradiol action
A
E-R ->
- Bone density and epiphyses closure
- Regulation of male reproductive tract fluid
10
Q
Transdermal androgen Tx
A
Testosterone
11
Q
IM deposit androgen Tx
A
Testosterone cypionate
12
Q
Oral androgen Tx
A
- Methyltestosterone
- Oxandrolone
- Danazol
13
Q
Endometriosis androgen Tx
A
Danazol
14
Q
Unusual clinical uses for androgens
A
Hereditary angioedema
- AIDS muscle wasting
- Severe anemia (stimulate erythropoiesis)
15
Q
Androgen Tx tumor risk
A
Liver tumors
