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Pharm > Pharm 49 Cram CSV > Flashcards

Pharm 49 Cram CSV Flashcards

1
Q

DOC for influenza A

A

Amantadine

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2
Q

DOC for RSV

A

Ribavirin

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3
Q

DOC for CMV retinitis

A

Ganciclovir

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4
Q

SE for ganciclovir

A

Neutro, leuko and thrombocytopenia

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5
Q

Anti?viral agents associated with Stephen Johnson syndrome

A

Nevirapine, amprenavir

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6
Q

HIV antiviral class known to have severe drug interactions by causing inhibition of metabolism

A

Protease inhibitors

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7
Q

Antivirals that are teratogens

A

Delavirdine, efavirenz, and ribavirin

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8
Q

Antivirals associated with neutropenia

A

Ganciclovir, zidovudine, saquinavir, and interferon

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9
Q

HIV med used to reduce transmission during birth

A

AZT (zidovudine)

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10
Q

MOA for Acyclovir

A

inhibits viral DNA sysnthesis 1. Competition with deoxyGTP for viral DNA polymerase 2. chain termination

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11
Q

DOC for herpes simplex encephalitis and neonatal HSV infection

A

Intravenous acyclovir

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12
Q

Greater t1/2 than acyclovir

A

Valcyclovir

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13
Q

MOA for Docosanol (Abreva)

A

Inhibits fusion between plasma membrane and HSV envelope

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14
Q

What is required to activate Ganciclovir

A

protein kinase phosphotransferase UL97

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15
Q

What drug would you use to treat CMV

A

Ganciclovir

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16
Q

What is the differences in SE Ganciclovir vs Acyclovir

A

Ganciclovir has dose limiting hematoxicity

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17
Q

What drugs increase the levels of Ganciclovir

A

Probenecid & trimethoprim

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18
Q

What dual therapy is effective in delaying CMV retinitis

A

Ganciclovir & Fosarnet

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19
Q

MOA of Foscarnet

A

inhibits herpesvirus DNA & RNA polymerase & HIV reverse transcriptase

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20
Q

What drugs should be avoided when treating with Foscarnet due to nephrotoxicity

A

amphotericin B, pentamidine, aminoglycosides, Cidofovir

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21
Q

SE of Foscarnet

A

Hypocalcemia

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22
Q

Pt is on Pentamidine IV for PCP what drug should be avoided?

A

Foscarnet

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23
Q

Drug used against resistant strains of CMV or HSV

A

Cidofovir (does not depend on thymidine kinase)

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24
Q

IV cidofovir must be given with?

A

Probenecid to block active tubular secretion to decrease nephrotoxicity

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25
Q

What drugs are not useful against HIV?2

A

NNRTI’s

26
Q

Characteristics of NRTI’s

A
  1. prodrugs 2. Nonspecific kinase 3. Bone Marrow supression
27
Q

NRTI’s associated with dyslipidemia and insulin resistance

A

Zidovudine and Stavudine

28
Q

NRTI with significant allergy SE

A

Abacavir (ABC)

29
Q

NRTI with risk of peripheral distal sensory neuropathy

A

Didanosine (DDI), Zalcitabine

30
Q

CI for taking Emtricitabine (FTC)

A

Children, Prego, renal or hepatic failure, metronidazole, disulfiram

31
Q

Drug used prophylaxis in reducing HIV acquisition

A

Emtricitabine (FTC), Tenofovir

32
Q

Common mutation in Emtricitabine and Lamivudine

A

M184V/I

33
Q

Discontiuation of Lamivudine (ETC) is associated with hepatitis, why?

A

Lamivudine treats both HIV & HBV

34
Q

Lmivudine works synergistically with

A

Zidovudine(AZT) and Stavudine

35
Q

Drug favored over AZT due to decreased myelosuppression

A

Stavudine (d4T)

36
Q

Which drug should be avoid with lactose intolerance

A

Tenofovir

37
Q

SE of Tenofovir

A

bone toxicity (osteomalacia)

38
Q

What drug inhibits Zalcitabine in vitro?

A

Lamivudine

39
Q

MOA of Zidovudine (AZT)(ZDV)

A

blocks DNA polymerase

40
Q

Which drug is the most hepatotoxic of the NRTIs

A

Zidovudine (AZT) (ZDV)

41
Q

Characteristics of NNRTI’s

A
  1. Not Pro drug 2. No bone marrow suppression 3. metabolism through CYP
42
Q

Which NNRTI prolongs the elimination of indinavir and saquinavir allowing PID

A

Delavirdine

43
Q

SE of Efavirenz (NNRTI)

A

Nightmares

44
Q

NNRTI that prevents vertical transmission

A

Nevirapine

45
Q

Common things among Protease inhibitors

A
  1. Aspartate protease 2. insulin resis 3. QT prolongation
46
Q

PI that has least amount of dyslipidemia

A

Atazanavir

47
Q

Pi that must be co?administered with ritonavir

A

Darunavir

48
Q

PI that is CI in pts with sulfa allergy

A

Fosamprenavir & Tipranavir

49
Q

PI with most common SE dyslipedemia

A

Indinavir

50
Q

Which PI is contraindicated with rifampin

A

lopinarvir/ritonavir

51
Q

Which PI can be admisitered to PREGO

A

Nelfinavir

52
Q

Which PI is most CI in someone with QT prolongation

A

Ritonvair

53
Q

MOA for Enfuvirtide

A

binds to gp 41 subunit of viral envelope glycoprotein, prevents conf. change

54
Q

SE of enfuvirtide

A

painful erythematous nodules

55
Q

MOA for Maraviroc

A

binds to CCR5

56
Q

Resistance to Maraviroc is associated with

A

V3 loop of gp 120

57
Q

SE Maraviroc

A

CYP3A, postural hypotension, hepatox, increased cardiovascular risk

58
Q

MOA of Raltegravir

A

binds integrase (inhibits strand transfer and final step)

59
Q

MOA of Ribavirin

A

inhibits viral RNA dependent Polymerase

60
Q

Drugs that affect uncoating

A

Amantadine & Rimantadine

61
Q

SE of Amantadine

A

Atropine like, livedo reticularis

62
Q

Areosol given to infants with RSV

A

Ribavirin

Pharm (1 decks)

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