Pharm Flashcards
Gq vs Gs
Gq –> incr Ca and PKC –> incr MLCK –> contracts SM
Gs –> incr cAMP –> decr MLCK –> relaxes SM
Effect of prog and CRH on cAMP?
keep it high so SM relax
PGE2 (Dinoprostone)/PGE1 (Misoprostol)effects on EP1 or EP2-3-4 receptors?
(prostaglandins _
ADR
EP1 –> Gq –> myometrial contractions
EP2-3-4 –> Gs –> cervix ripening/dilation
ADR: GI cramps, diarrhea, nausea
PGF2a
FP –> Gq –> contraction
Oxytocin & admin
OXT –> Gq
IV or IM, NOT oral
EPI
B2 –> Gs
Drugs for each stage of labor:
- PGs for dilation and effacement
- PGs and OXT and VSCC L type
- hemorrhage contianed by oxytocin
Ergot alkaloids - large dose indication?
to control bleeding via sustained contraction of uterus if oxytocin not working
NSAID Indomethacin
ADR
Inhib, oral or IV
24-32 weeks (drops PGs)
ADR: premaure closure of ductus arteriosis - PULM HTN
Nifedipine
CCB, inhib, ORAL
32-34 weeks
NOT for renal dysfxn
REFLEX TACHY or drop in BP
Terbutaline
B2 agonist so, inhib
IV, oral, SC
ADR: anxiety, hypOkalemia, hypERglycemia
Mifepristone
competitive progesterone receptor antagonist
abortive
if
Oxytocin (when sensitive)
Uterus not sensitive until 20-36 weeks
sensitive to PGs throughout preg
PDE5 ED drugs work how?
Stop breakdown of cGMP so maintain vasodilation effect
cGMP rise due to NO activity
Most effective ED drug?
all equal
ED drug DDIs?
a-blockers, nitrates for chest pain may cause an unsafe drop in blood pressure
ED drugs metabolized by?
CYP3A4
ED drug longest half life?
Tadalfil
Sildenafil with food or on empty stomach?
empty stomach (also has risk of visual disturbance)
Only indication for MgSO4?
Preeclampsia
