Pharm 422

Question 1

These anti-diabetic drugs block the reabsorption of glucose in the proximal tubule of the kidney and allow glucose to be excreted in the urine.

Answer 1

SLGT-2 inhibitors

Question 2

These anti-diabetic drugs:
Canagliflozin (Invokana)
Dapagliflozin (Farxiga)
Empagliflozin (Jardiance)
are part of what class?

Answer 2

SLGT-2 inhibitors

Question 3

side effect of these anti-diabetic drugs include:
Hypotension
dehydration
hyperkalemia
weight loss
UTI
Genital fungal infection
Increase in urination
small increase in LDL 
decrease in renal function

Answer 3

SLGT-2 inhibitors

Question 4

Sulfonlyureas & antihypertensive drugs can have an interaction with these anti-diabetic drugs

Answer 4

SLGT-2 inhibitors

Question 5

SLGT-2 inhibitors contraindicated in what conditions or populations?

Answer 5

Severe renal impairment
Type I Diabetes
Children & breastfeeding

Question 6

Gliflozins are part of what anti-diabetic med family?

Answer 6

SLGT-2 inhibitors

Question 7

GLP-1 Agonist

non-insulin injectable

Answer 7

Incretins

Question 8

MOA of Incretins (GLP-1 agonist)

Answer 8

• Promotes insulin release from beta pancreatic cells
• Suppresses release of glucagon from alpha cells
• Slows gastric emptying

Question 9

Promotes insulin release from beta pancreatic cells
Suppresses release of glucagon from alpha cells
slows gastric emptying

Answer 9

MOA of Incretins (GLP-1 agonist)

Question 10

What class of anti-diabetc drugs do these belong in?
Exenatide (Byetta, Bydureon)
Liraglutide (Victoza)
Lixisenatide (Adlyxin)
Dulaglutide (Trulicity)

Answer 10

GLP-1 agonist drugs (Incretins)

Question 11

Less hypoglycemia with these medications, insulin is only released in response to food. So, unlike the sulfonlyurias that Stimulate insulin release regardless of food intake

Answer 11

GLP-1 agonist drugs (Incretins)

Question 12

Contraindications for GLP-1 agonist drugs (Incretins)

Answer 12

Type I diabetes
gastroparesis
Acute pancreatitias
Preg Cat C

Question 13

If thyroid CA is present, avoid this class of med anti-diabetic drugs

Answer 13

GLP-1 agonist drugs (Incretins)

Question 14

weight loss 8-10lbs common with this class of med anti-diabetic drugs
Preg Cat C

Answer 14

GLP-1 agonist drugs (Incretins)

Question 15

Side effects of GLP-1 agonist drugs (Incretins)

Answer 15

N/V, diarrhea, dyspepsia & hypoglycemia when paired with sulfonlyurea

Question 16

DPP-4 Inhibitors MOA

Answer 16

slows inactivation of the incretins (GLP-1 & GIP) keeping glucose levels low by inhibiting DPP-4 enzyme

Question 17

“Gliptins”

Answer 17

DPP-4 Inhibitors

Question 18

Enhance activity of GLP-1, they inhibit DPP-4 and it leads to increase in the secretion of insulin & supresses the
release of glucagon by the pancreas.

Answer 18

DPP-4 Inhibitors

Question 19

side effects of DPP-4 inhibitors

Answer 19

URI, UTI, Headache, angioedema

Question 20

Can increase hypoglycemic effects of DPP-4 inhibitors

Answer 20

sulfonylureas, insulin & ACE-I

Question 21

you get increased levels of gliptons (DPP-4 inhibitors) with these drugs

Answer 21

SSRIs
salicylates
Quinolone antibiotics

Question 22

you get decreased levels of gliptons (DPP-4 inhibitors) with these drugs

Answer 22

CYP 3A4 inducers
Quinolone antibiotics
Thiazide diuretics

Question 23

Dosing for DPP-4 inhibotrs

Answer 23

• One oral in the morning

- Monotherapy or in combination with other antidiabetic drugs

Question 24

ADA & AACE recommend HbA1c less than for
to be considered diabetic
and to reach treatment goals
FBG

Answer 24

> 6.5 - 7 %
< 6.5%

> 126 mg/dL