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MS2 Block 2 > Pharm > Flashcards

Pharm Flashcards

1
Q

Cox 1 actions

A 
renal function
bronchodilation/constriction
acute prostaglandin production
gastric cytoprotection
platelet aggregation
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2
Q

cox 2 actions

A

renal function
bronchodilation/constriction
sustained prostaglandin production

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3
Q

COX1 and COX2 shared functions

A

renal function

bronchodilation/constriction

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4
Q

COX1 only functions

A

gastric cytoprotection

platelet aggregation

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5
Q

PGE1

A

vasodilation

maintenance of patent ductus arteriosus

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6
Q

PGE2

A 
vasodilation
diuresis- Na and K loss in urine
patent ductus arteriosus
gastric cytoprotection
pain sensitization
fever
uterine and GI smooth muscle contraction
relaxation of respiratory smooth muscle
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7
Q

PGF2

A

vasoconstriction
increased aqueous humor drainage
uterine, GI, and respiratory smooth muscle contraction

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8
Q

changes in vessel diameter

A

vasodilation- PGE1, PGE2, PGI2

vasoconstriction- PGF2, TXA2

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9
Q

uterine changes

A

contraction- PGE2, PGF2

relaxation- PGI2

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10
Q

GI contraction

A

PGE2

PGF2

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11
Q

respiratory changes

A

contraction- PGF2, TXA2, leukotrienes C, D, E

relaxation- PGE2, PGI2

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12
Q

PGI2

A

vasodilation- diuresis, NA and K loss in urine
gastric cytoprotection
pain sensitization
fever
relaxation of uterine and respiratory smooth muscle
prevents spontaneous platelet aggregation- inhibits TXA2

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13
Q

gastric cytoprotection

A

PGE2

PGI2

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14
Q

pain sensitization

A

PGE2
PGI2
leukotrienes (LTB4)

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15
Q

fever

A

PGE2

PGI2

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16
Q

TXA2

A

vasoconstriction
contraction of respiratory smooth muscle
platelet aggregation

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17
Q

platelet aggregation

A

inhibit- PGI2

promote- TXA2

18
Q

LTC4, LTD4, LTE4

A

bronchoconstriction

increased vascular permeability

19
Q

LTB4

A

chemoattraction

pain sensitization

20
Q

EP1

A

fever

21
Q

EP2

A

vascular smooth muscle relaxation

22
Q

EP3

A 
vascular smooth muscle relaxation
decreased gastric acid secretion
increased gastric mucus secretion
uterine contraction
fever
23
Q

EP4

A

vascular smooth muscle relaxation

pain sensitization

24
Q

budesonide

A

short half life
used in asthma inhalers
easily penetrates airway mucosa

25
Q

dexamethasone

A

very potent
long half life
oral, parenteral, topical
multipurpose

26
Q

fluticasone

A

asthma inhalers and nasal sprays
medium potency
short half life

27
Q

hydrocortisone (cortisol)

A

low potency OTC for skin
also used PO and parenteral
used for adrenal insufficiency replacement
medium half life

28
Q

mometasone

A

medium potency
asthma and skin
not metabolized in skin, so can cause local side effects
systemically absorbed
*not as commonly used as budesonide or fluticasone

29
Q

prednisone

A

long half life
prodrug metabolized by liver
PO only
used for inflammatory conditions

30
Q

prednisolone/methylprednisolone

A

active metabolite of prednisone
used in hepatic disease patients
PO, inject, eye drops
no bioactivation required

31
Q

triamcinolone

A

oral, injection, topical
potency depends on formulation
causes skin issues like mometasone

32
Q

ibuprofen

A

COX1
pain, fever, OA, RA, dysmenorrhea
topical for MSK and dental
pediatric- fever

33
Q

naproxen

A

COX1
similar to ibuprofen
LONG half life
used 2x daily for arthritis

34
Q

piroxicam

A

COX1
OA, RA
long half life- once daily
noncox mediated anti-inflammatory effects
high doses more likely to cause peptic ulcers than other NSAIDs

35
Q

indomathacin

A

COX1
extensive toxicities with severe sideffects
used to reverse acute disorders- pericarditis, patent ductus closure, acute gout attack
few, night time doses

36
Q

sulindac

A 
COX1
RA, OA, gout
polyp regression in familial adenomatous polyposis
prodrug
less GI irritation
high CNS effects
enterohepatic recycling
37
Q

ketoralac

A 
COX1
analgesic- better than morphine
used with opioids and reduces required opioid dose
not anti-inflammatory
high risk renal toxicity
do not use more than 5 days
renal impairment- contraindication
38
Q

nabumetone

A 
COX1 and COX2
OA, RA, pain
non acid NSAID
metabolized to weak acid to be activated
>24 hour half life
pseudoporphyria and photoinsensitivity
39
Q

etodolac

A

COX2
OA, RA
less GI ulceration

40
Q

diclofenac

A

OA, RA
less likely to cause GI ulcerations
topical gel for localized arthritis
more likely to elevate liver enzymes

41
Q

celecoxib

A

cox 2 selective
OA, RA
promote regression of polyps
lower GI ulceration, but can delay healing of existing ulcers
increased risk of Cardiovascular adverse efects

42
Q

meloxicam

A

cox 2 selective
OA, RA
low doses have fewer GI sed effects
activity is dose dependent

MS2 Block 2 (1 decks)

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