Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharm 4 > Pharm 4 all drugs > Flashcards

Pharm 4 all drugs Flashcards

1
Q

Phenytoin

A

Na+ channel blocker
1st line=
AE=
other=

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Carbamazepine

A

Na+ channel blocker
1st line=
AE=
Other=

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Oxcarbazepine

A

Na+ channel blocker

Treats=

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Valproic acid

A 
Na+ channel blocker
Ca T-type blocker
increase GABA production
decrease GABA metabolism
1st line=
AE=
other=
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Lamotrigine

A 
Na+ channel blocker
decrease GLUT release
Treats=
Rash and Aseptic meningitis
Other use=bipolar disorder
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Topiramate

A 
Na+ channel blocker
increase GABA receptor effects 
decrease Kainate GLUT receptor effects
Adjunct therapy
AE=
other=
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Zonisamide

A 
Na+ channel blocker
Ca T-type channel inhibitor
increase GABA effects
increase DA/5HT effects
Adjunct therapy
Alt. to valproic acid
weight loss
other=
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Lidocaine

A

Na+ channel blocker
Treats=
Mexiletine

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Lacosamide

A

Na+ channel blocker and neuroprotective
Adjunct therapy for partial seizures and used for neuropathic pain
AE=
Other=

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Retigabine

A

K+ channel activator
Adjunct for partial seizures
AE=urinary retention

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Phenobarbitol + Primidone (prodrug)

A

GABAa allosteric activators
increase duration of GABA Cl- channel opening
1st line=Seizures in young children and infantile spasms
2nd line=
AE=CNS depression and physical dependence

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Diazepam, Lorazepam, Clonazepam, Clorazepate

A

GABAa allosteric activators; increase frequency of GABA Cl- channel opening
Acute Tx=Status epilepticus
AE=
Other= paraldehyde and flumazenil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Tiagabine

A

GABA reuptake inhibitor
Adjunct therapy
may exacerbate=absence seizures

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Ethosuximide

A

Thalamic T-type Ca+ channel Blocker
1st=absence seizures
EFGH
Tox=

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Gabapentin and Pregabalin

A

Selective alpha2delt1 V-G Ca channel blocker
Neuropathic pain
Parent drugs cleared unchanged by kidney

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Levetiracetam

A

Ca channel affinity
blocks synaptic vesicle fusion
adjunct monotherapy

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Morphine

A

3B

6B

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Heroin

A

2-4X

Converted to morphine in brain

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Hydromorphone and Oxymorphone

A

8-10X

same efficacy shorter duration

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Codeine and Dextromethorphan

A 
1/10th
anti-tussive
weak analgesic
prodrug
CYP2D6
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Oxycodone
Hydrocodone
dihydrocodeine

A

similar potency
hydrocodone=short acting
prodrugs-CYP2D6

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Meperidine

A 
1/8th potency
shorter duration
post-surgical analgesia
not for chronic pain
increase seizure risk
Less smooth muscle spasms
no miosis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Fentanyl

A

80-100X
fast onset, short duration
intraoperative anesthesia
periphral nerve blocks

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Levorphanol

A

long t1/2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
Q

Methadone

A

4X oral
long half life
narcotic dependence
cardiac instability

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
26
Q

LAMA

A

very long half

narcotic dependence

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
27
Q

Diphenoxylate and loperamide

A

40-50X more potent
diarrhea
does not cross BBB

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
28
Q

Nalorphine and cyclazocine

A

Kappa3 agonist
mu antagonist
psychokinetic effects
Dysphoria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
29
Q

Pentazocine

A

Kappa and delta agonist

mu antagonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
30
Q

Butorphanol

A

Kappa agonist
mu antagonist
5X more effective in women

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
31
Q

Nalbuphine

A

Kappa agonist
Mu antagonist
ambulance analgesia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
32
Q

Buprenorphine

A

Mu partial agonist
Kappa3 partial agonist
Kappa1 antagonists
strong analgesic for drug addicts

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
33
Q

Salvinorin A

A

Selective Kappa1 agonist

use naloxone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
34
Q

Tramadol

A

Mu and delta agonist
SNRI
alpha 2 agonist

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
35
Q

Tapentadol

A

Mu and delta agoinst

NRI

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
36
Q

Naloxone

A

Addiction deterrent in combos:
Oral use for pain-no block
IV use-blocks MuR

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
37
Q

Naltrexone

A

for dependence-hepatotoxic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
38
Q

Nalmefene

A

orally active

no hepatotoxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
39
Q

Capsaicin

A

substance P

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
40
Q

Methohexital

A

anesthesia induction-can be given rectally to children

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
41
Q

Thiopental

A

Anesthesia induction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
42
Q

Thiamylal

A

USA

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
43
Q

Secobarbital

A

Insomnia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
44
Q

Pentobarbital

A

anxiety

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
45
Q

Phenobarbital

A

anticonvulsant-1st line for young children and infants

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
46
Q

Midazolam

A

conscious sedation-same day surgeries

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
47
Q

Triazolam

A

Sedative hypnotic-sleep onset disorders

48
Q

Oxazepam

A

situational anxiety

49
Q

Chlordiazepoxide

A

anxiety disorders

50
Q

Temazepam

A

sedative-hypnotic=sleep maintenance disorders

51
Q

Alprazolam

A

anxiety disorderrs-depression, panic disorder

52
Q

Lorazepam

A

Status epilepticus DOC-bc water soluble benzodi

53
Q

Clonazepam

A

chronic anxiety

54
Q

Diazepam

A

anxiety disorders, IV anesthetic
Status epilepticus 2nd choice
thrombophlebitis

55
Q

Flunitrazepam

A

Date rape drug-sedative-hypnotics and anterograde amnesia

56
Q

Flumazenil

A

competative inhibitor at benzo binding site on GABAa receptor
Use-overdose reversal

57
Q

Zolpidem

A

2 hr

58
Q

Zaleplon

A

1 hr

59
Q

Eszopiclone

A

NBH

60
Q

Buspirone

A

MOA-5HT1A receptor agonist

GAD

61
Q

Beta-blockers

A

performance anxiety

62
Q

Chloral hydrate

A

GABAa allosteric activator
insomnia
should not use

63
Q

melatonin

A

mild sleep disorders

64
Q

meprobamate

A

anti-anxiety

sedative-hypnotic

65
Q

Carisoprodol

A

sedative hypnotic

66
Q

Catecholamine releasers

A

Reserpine-decrease DA to NE conversion/vesicular loading

Guanethidine-decrease presynaptic NE release

67
Q

ephedrine

A

also an alpha and Beta agonist==>direct and indirect acting

68
Q

pemoline

A

longer-acting, slower onset
caution-hepatic complications/failure
tyramine-many aged foods and fermented drinks

69
Q

Cocaine

A

RI

70
Q

Mazindol

A

RI

71
Q

Sibutramine

A

weight loss

72
Q

modafinil

A

used in military for alertness>psychomotor effects

73
Q

Atomoxetine

A

NRI antidepressant-non-stim for adhd

milder effects

74
Q

Bupropion

A

atypical antidepressant (blocks reuptake of both NE and DA

75
Q

Guanfacine

A

decreases hyperactivity in adhd

76
Q

Clonidine

A

anxiolytic, anti-HTN, neuropathic pain, migraine prophyaxis

77
Q

Pargyline

A

MAO-B inhibtor

78
Q

Entacapone

A

COMT inhibitor

79
Q

Tertiary Amine TCAs

A

more anti-cholinergic side effects predominantly block 5HT reuptake, Long acting w active metabolites

80
Q

Amitriptyline

A

cardioprotective, neurogenic pain

81
Q

Clomipramine

A

OCD

82
Q

imipramine

A

long-acting and im forms available

83
Q

Trimipramine

A

increase sedation, moderate anti-cholinergic

84
Q

Doxepin

A

increase sedation, hypnotic,

85
Q

DA-CLIT

A

Doxepin, Amitriptyline, Clomipramine, Imipramine, Trimipramine

86
Q

Secondary amine TCAs

A

Less anti-cholinergic side effects

Block 5HT and NE reuptake

87
Q

Nortriptyline

A

indicated in elderly

88
Q

Protriptyline

A

no sedation (for sleepy depressives)

89
Q

Desipramine

A

metabolite of imipramine

90
Q

Maprotiline

A

increase seizure potential (stronger effects on NE)

91
Q

Amoxapine

A

also anti-dopaminergic (antipsychotic-like)

92
Q

DAMPN

A

Desipramine, Amoxapine, Maprotiline, Protriptyline, Nortriptyline

93
Q

SSRIs

A 
Selective 5HT reuptake inhibitors==> increase 5HT
Monopolar depression (1st choice) Premenstrual dysphoriic disorder, panic disorders, GAD
94
Q

SNRIs

A

slective 5HT and NE reuptake inhibitors==> increase 5HT and increase NE
sleepy depressives
neuropathic pain
fibromyalgia
GAD
Less anti-cholinergic and anti-histamines effects than TCAs.

MiDVD
Milnacipran
Duloxetine
Venlafaxine
Desvenlafaxine
95
Q

SSRIs

A

Dont give w Tamoxifen
CYP2D6
can use Citalopram

96
Q

MAOIs

A

Tranylcypromine, Isocarboxazid, Phenelzine
increase
increase norepinephrine and 5HT

97
Q

Bupropion

A

MOA-Blocks NE and DA reuptake
anti-depressant and adhd
no sexual side effects

98
Q

Nefazodone

A

5HT mechanism hepatotoxic

99
Q

Trazodone

A

5HT reuptake inhibitor
sedative-hypnotic insomnia
priapism

100
Q

Vilazodone

A

partial 5HT1A agonist

anti-depressant and anxiolytic

101
Q

Mirtazapine

A 
alpha 2 antagonist: increase norepinephrine and 5HT
alpha 1 antagonist
5HT2A antagonist
sedation 
weight gain
102
Q

Reboxetine

A

Selctive NE reuptake inhibitor (NRI)

sleepy depressives

103
Q

Lithium

A

Nephrogenic DI
No hyperthermia
decrease Li levels-osmotic, acetazolamide
increase Li levels-thiazides, loops

104
Q

Lamotrigine

A

anticonvulsant-
Na+ channel blocker
bipolar depression
minimal risk of inducing mania

105
Q

Valproic acid

A

anticonvulsant
Na+ channel blocker
Ca2 and GABA effects
DOC-bipolar disorder

106
Q

Carbamazepine

A

anticonvulsant- Na+ channel blocker

treatment resistant bipolar depression

107
Q

Carbidopa

A

DOPA decarboxylase inhibitor

108
Q

Amantadine

A

DA releaser: Early stage

109
Q

Bromocriptine, Pergolide, pramipexole, ropinirole

A

later

110
Q

entacapone and tolcapone

A

COMT inhibitors

early

111
Q

selegiline

A

MOA B inhibitor

decrease presynptic DA degradation

112
Q

Trihexyphenidyl and benztropine

A

Anticholinergics

113
Q

Riluzole

A

ALS
post synaptic glut receptor inhibitor (NMDA and Kainate-type)
V-G Na+ channel blocker

114
Q

Baclofen

A

GABAb agonist (GPCR)

115
Q

Tizanidine

A

alpha 2 agonist

Pharm 4 (1 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions