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Pharm Flashcards

1
Q

Amingoglycoside tox-

A

OTO, nephro, NMHJ block. Teratogenic

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2
Q

Linezolid - tx? Concern for?

A

VRE, VRSA,

Concern - serotonin syndrome.

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3
Q

Tetracycline concerns?

A

Photosenstiivity rash - teeth discoloration

Dont give in pregnant or children under 8y.o (doxy at least)

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4
Q

Macrolide tox?

A

Cholestatic hepatitis

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5
Q

Clinda tx?

A

Anaerobes, MRSA, Osteo (good bone concentration)

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6
Q

Fluoroquinodone concern?

A

Tendon

Also - Cipro tx pseudomonas

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7
Q

Metronidazole - mechanism of action

A

Free radical generation -

Tx anaerobes + a lot more .

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8
Q

TMP SMX - tox?

PPX for?

A

Anemia, G6PD trigger, SS trigger.

Tx - pseduo, nocardia,

PPX PCP, toxo, transplant

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9
Q

RIPE -

Side effects? for all? for one?

A

All have hepatotox

Pyrazidamine - Hyperuricemia

I know the others

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10
Q

Amphotericin tox?

Capsofung in Tox?

A

Neprhotox - HypoK, HypoMg

Caspofungin - Flushing, GI upset

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11
Q

Acyclovir,

Gangcylcovir

Foscarnet

tx?

A

ALL ARE NEPHROTOX.

Acyclovir - cystalline nephropathy (obsturctive)

Gangcylcovir - CMV - CYTOPENIA, renal tox

Foscarnet Used to tx CMV retinits - Nephrotox.

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12
Q

Maraviroc - Mech -

A

CCr5 - attachment block block gp120.

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13
Q

Enfuviritide - mech -

A

Enfuviritide - inbhits ENTRY - blocks gp41

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14
Q

RTI - nucleotide

RTI - nonnucleotide

Which? Tox?

A

RTI nucleotide - ZDV, lamivudine, Tenofovir, Didanosine, Abacavir - Bone marrow tox. LACTIC ACIDOSIS, NEUROPATHY.

RTI NONnucl- - Efavierenz, Nevirapine (1 shot at birth)m Delaverdine. LESS MARROW TOX. RASH, HEPATOTOX

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15
Q

Raltegravir - Mech - tox

A

Integrase inhibtor

Tx - Hypercholesterolemia

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16
Q

Navirs - Mech - Tox?

A

Protease inhbiitor. Hyperglycemia. Nephropathy.

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17
Q

Which anesthetic DEC IOP?

A

Thipental (barbitutatE) - DEC ICP.

Rapid entry into bain and redispribution.

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18
Q

Types of NM Blocker?

Depol

Nondepol

A

NM Blcoker - Nicotoninc motor receptor

Depol - Succ - Achr Agonist - Tox HyperK, HyperCa

  • Phase 1 - no antide
  • Phase 2 - cholinesterase inhbiitor

Nondepol - Turbocurare, mivacurium, RONIUMS. - Achr Competitive antagonists

Reversal - Neostigmine + Atropine (prevents muscarining side effects) `

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19
Q

Tox Tx.

Copper

Fe

Cyanide

A

Copper - Penacillamine

FE - Deferoxamine

Cyanide - Nitrites + SUlfate + Hydroxy Cobalamin

20
Q

Tox tx

Lead

mercury

A

Lead - EDTA, Dimercaprol

mercury - Dimercaptrol

21
Q

Tox tx

Heparin

TPA

Warfarin

A

Heparin - protamin

TPA - aminocaproic

Warfarin - FFP + Vit K

22
Q

Tx Hyper!

K

Mg

TCA

A

Hyper K - Ca gluconate

Hyper Mg - Ca gluconate

TCA poixoni - Sodium Bicarb

23
Q

Aspirin tox side effects.

ABG?

A

Aspiriing - asthma, chronic rhinit,s polpyps

Tox tinnitus, fever

ABG - PH NORMA 7.4
Because Met acidosis (anion gap!) + resp alkalosis.

24
Q

ACE i tox?

A

Cough, angioedema HYPERK!

25
Q

Lead tox?

A

Abd pain, constipation, neuropathy, neprhopathy, neuropsych, mylagias, HTN

26
Q

Zinc def causes?

A

Alopecia, DEC food tase, pustular skin lesions

27
Q

VIT D tox - How to differentate from DKA?

A

HyperCa, polyuria, abd pain, UA IS NORMAL (abnormal in DKA)

28
Q

Vit A tox -

A

dry skin, blurry vison, pseudotumor

29
Q

Primidone tox can cause?

A

Acute intermitten porphyria - abd pain, hallucinatiosn

30
Q

Transplant pt ppx?

A

Bactrim for PCP

31
Q

Benzo tox presentation?

A

MAY NOT HAVE PUPILLARY OCNSTRICTION - Slurred speech, no severe resp distress.

32
Q

Megestrol acetate - mech - for?

A

Progesteron - use for cachexia in CA pt. Cannabis does not work.

33
Q

Tx for Lyme in Pregnancy?

A

Amoxicillin

34
Q

EPO side effect

Therapeutic EPO concern?

A

HTN!! headache,.

If you are therapeutically given EPO, must give Iron to prevent iron deficiency.

35
Q

Drug induced esophagitis

A

KCl, Tertracylcine, NSAID, Alendronate, Fe

36
Q

PPI/H2 blocker increases risk for?

37
Q

Cocaine preventative measure? Pharmacotherapy?

A

No pharm. 12 step and psychotherapy. Cocaine anonymous

38
Q

Phenytoin tox - 3 major signs

A

horizontal nystagmus, cerebellar ataxia, confusion

39
Q

Lithium tox

A

tremor, hyperreflexia, ataxia, seizures.

40
Q

Cylophosphamide tox

A

hemorrhagic cystitis + BLADDER CA.

41
Q

Which immunosuppressant gives you cochlear dysfunction?

A

Cisplatin carboplatin (amifostine)

42
Q

Warfarin bleed give?

A

Vit K + Prothrombin complex concentrate (vit K clotting factors with RAPId reversal), Can give FFP if PCC not available.

43
Q

Terbinafine, fluconazole tox

A

– hepatotox . Amphotericin is the one with neprhotox

44
Q

Kaposi tx in those reftractior to antiretrovirals?

A

Adiramycin and vinblastine

45
Q

Aspirin tox can give

A

– Bicarb to alk urine.

46
Q

Benzo tox in ED tx

A

– let them sleep. Flumazenil can precipitate withdrawal seizures.

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