Pharm Flashcards
Leucovorin can enhance the use of what chemotheraputic agent in the treatment of colorectal cancer?
Fluorouracil
Capecitabine may increase a persons INR if they are also on what other drug?
Warfarin
Which of the following drugs requires renal dose adjustment?
5FU
Capecitabine
Gemcitabine
Leucovorin
Capecitabine
VEGF inhibitors causes what common side effect? What’s the purpose of this therapy?
HTN
prevent tumors from using angiogenesis to feed themselves
What should be carefully monitored when using VEGF inhibitors?
urine protein as nephrotic syndrome may occur
Which two drugs are associated with dermatitis and Mg wasting?
cetuximab and panitumumab
Tyrosine kinase inhibitors have what suffix?
inib or enib
What are some common side effects of erlotinib?
rash and diarrhea
Erlotiniib should be taken on a full or empty stomach?
empty
What drug should be taken with a low fat breakfast?
Regorafinib
Which drugs are antimetabolites?
Cape-cita-bine
5FU
Gem-cita-bine
Whats is the general MOA for the antimetabolites?
Cell cycle specific for S-phase.
Require metabolic activation
Synergy with radiation
Block DNA syn
The antimetabolites have three major specific MOA?
Inhibits DNA, RNA, and Thymidylate synthase and nucleosides needed for DNA
Leucovorin has what effect and toxicity?
enhances 5FU enhancing binding of Fdump
toxicity-stomatitis, myelosuppression
Capecitabine has what effect?
Oral pro-drug 5FU. Increases intra-tumor drug concentration decreases side effects.
What are some major toxicities of the antimetabolites?
Hand foot syndrome -red swelling, DPD deficiency (increase toxicity by decreasing drug metabolism) . Change drug dosing.
Gemcitabine has what effect and toxicities?
resistant to DNA repair mech
toxicity-increase RBC, avoid within a week of radiation therapy
Which mabs are VEGF inhibitors?
BZR
Bevacizumab
Zic-aflibercept
Ramucirumab
Black box for VEGF inhbitors?
GI perforation
poor healing
hemmorrhage
Anti epidermal growith factor recptors Mabs (EGFR)
PC
panitumumab
Cetuximab
Prevent activation of receptor kinases
TK inhbitors what do they do, how does this fight cancer and what are some drug names
Inhibits TK receptors, b/c many oncogenes are driven by them.
Erlotinib Regorafenib
Regorafenib MOA
inhibit TK that promote angiogenesis and tumor growth
What are the three Hep b drugs?
lamivudine, tenofovir entecavir
Hep C drugs?
Ribavirin, simeprevir, sofosbuvir, harvoni (cure)
