Pharm

Question 1

Leucovorin can enhance the use of what chemotheraputic agent in the treatment of colorectal cancer?

Answer 1

Fluorouracil

Question 2

Capecitabine may increase a persons INR if they are also on what other drug?

Answer 2

Warfarin

Question 3

Which of the following drugs requires renal dose adjustment?

5FU
Capecitabine
Gemcitabine
Leucovorin

Answer 3

Capecitabine

Question 4

VEGF inhibitors causes what common side effect? What’s the purpose of this therapy?

Answer 4

HTN

prevent tumors from using angiogenesis to feed themselves

Question 5

What should be carefully monitored when using VEGF inhibitors?

Answer 5

urine protein as nephrotic syndrome may occur

Question 6

Which two drugs are associated with dermatitis and Mg wasting?

Answer 6

cetuximab and panitumumab

Question 7

Tyrosine kinase inhibitors have what suffix?

Answer 7

inib or enib

Question 8

What are some common side effects of erlotinib?

Answer 8

rash and diarrhea

Question 9

Erlotiniib should be taken on a full or empty stomach?

Answer 9

empty

Question 10

What drug should be taken with a low fat breakfast?

Answer 10

Regorafinib

Question 11

Which drugs are antimetabolites?

Answer 11

Cape-cita-bine
5FU
Gem-cita-bine

Question 12

Whats is the general MOA for the antimetabolites?

Answer 12

Cell cycle specific for S-phase.
Require metabolic activation
Synergy with radiation
Block DNA syn

Question 13

The antimetabolites have three major specific MOA?

Answer 13

Inhibits DNA, RNA, and Thymidylate synthase and nucleosides needed for DNA

Question 14

Leucovorin has what effect and toxicity?

Answer 14

enhances 5FU enhancing binding of Fdump

toxicity-stomatitis, myelosuppression

Question 15

Capecitabine has what effect?

Answer 15

Oral pro-drug 5FU. Increases intra-tumor drug concentration decreases side effects.

Question 16

What are some major toxicities of the antimetabolites?

Answer 16

Hand foot syndrome -red swelling, DPD deficiency (increase toxicity by decreasing drug metabolism) . Change drug dosing.

Question 17

Gemcitabine has what effect and toxicities?

Answer 17

resistant to DNA repair mech

toxicity-increase RBC, avoid within a week of radiation therapy

Question 18

Which mabs are VEGF inhibitors?

Answer 18

BZR
Bevacizumab
Zic-aflibercept
Ramucirumab

Question 19

Black box for VEGF inhbitors?

Answer 19

GI perforation
poor healing
hemmorrhage

Question 20

Anti epidermal growith factor recptors Mabs (EGFR)

Answer 20

PC
panitumumab
Cetuximab

Prevent activation of receptor kinases

Question 21

TK inhbitors what do they do, how does this fight cancer and what are some drug names

Answer 21

Inhibits TK receptors, b/c many oncogenes are driven by them.

Erlotinib Regorafenib

Question 22

Regorafenib MOA

Answer 22

inhibit TK that promote angiogenesis and tumor growth

Question 23

What are the three Hep b drugs?

Answer 23

lamivudine, tenofovir entecavir

Question 24

Hep C drugs?

Answer 24

Ribavirin, simeprevir, sofosbuvir, harvoni (cure)