pharm Flashcards
most potent estrogen secreted by the ovary and the primary estrogen present in the premenopausal woman
estradiol
a metabolite of estradiol with 1/3 estrogen potency. primary circulating estrogen after menopause created from conversion of andostendione in peripheral tiss
estrone
what are the therapeutic uses of estrogens
contraception (in combo c/ progestin); postmeno hormone replacement-vasomotor instability, vag atrophy; 1 hypogonad or premature menopause
ADE of estrogens
nausea, breast tender, postmeno bleed, inc risk thromboembolic event, stroke, endometrial CA
what can be done to offset risk of endometrial CA in postmeno c/ uterus
combo progestogen
what risks are combo therapy ass. c/
inc breast CA, MI, PE
what manmade prep from horses urine is used in prostate CA palliation
premarin
if pt wanted to avoid systemic effects of estrogen what med forms could she use
vag ring, topical cream, supossitory
if a pt had liver Dz what med form would you choose/be cautious of
transdermal patch skips first pass
combination of estrogen and progesterone daily
prempro
14 days estrogen, 14 days estrogen and progesteron
premphase- may cycle
what med may be effective in pt who do not respond to estrogen/progesterone
estrogen/ testosterone- may inc libido
estrogen antagonist binds to estrogen receptor but not productive-results in down regulation of estrogen
tamoxifen
what selective estrogen receptor modulator used in breast CA is also used for osteoporosis and has little effect on the endometrium
raloxifene
what are some non-hormonal preparations for menopause
gabapentin (neurontin); SSRI (paroxitine (paxil), venlafaxine (effexor), escitalopram (lexapro); isoflavones, black cohosh
