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Respiratory > Pharm > Flashcards

Pharm Flashcards

0
Q

Loratadine, fexofenadine, desloratadine, certirizine

A

2nd generation reversible H1 histamine receptor inhibitor

-decreased entry into CNS so less sedating

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1
Q

Diphenhydramine, dimenhydrinate, chlorpheniramine

A

1st generation H1 histamine receptor inhibitor

-Sedation, antimuscarinic, anti-alpha-adrenergic

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2
Q

Guafenesin

A

Cough expectorant, thins respiratory secretions

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3
Q

N-acetylcysteine

A

Mucolytic, breaks up mucous plugs in CF Pts by situating disulfide bonds.
(Also an antidote for acetominophen OD)

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4
Q

Dextromethorphan

A

Cough suppressant (antagonizes NMDA glutamate receptors), codeine analog. Can cause serotonin syndrome if given with serotinergic agents.

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5
Q

Pseudoephedrine, phenylephrine

A

MOA: alpha-adrenergic agonists
Toxicity: hypertension, CNS stimulation/anxiety (Pseudoephedrine)

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6
Q

Bosentan

A

Endothelin receptor antagonists, decrease pulm vascular resistance. Hepatotoxic

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7
Q

Sildenafil

A

Inhibit cGMP PDE5, prolong NO’s vasodilation.

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8
Q

Epoprostenol, iloprost

A

Prostacyclin analog, direct vasodilation in pulmonary and systemic beds. Inhibits platelet aggregation
Side effects: flushing, jaw pain

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9
Q

Salmeterol, formoterol

A

Long acting beta 2 agonists for prophylaxis

Adverse effects: tremor, arrhythmias

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10
Q

Fluticasone, budesonide

A

Corticosteroids: inhibit all cytokine synthesis, inactivated NF-kappa B to prevent production of TNF-alpha.

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11
Q

Ipatroprium

A

Competitive muscarinic receptor, prevents bronchoconstriction

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12
Q

Montelukast, zafirilukast

A

Block leukotriene receptors

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13
Q

Zileuton

A

Blocks conversion of arachidonic acid leukotrienes, 5-lipoxygenase pathway inhibitor.
Hepatotoxic

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14
Q

Omalizumab

A

Monoclonal anti-IgE antibody, binds unbound serum IgE and blocks being to FceRI

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15
Q

Theophylline

A

Bronchodilators by inhibiting phosphodiesterase, inc cAMP by reducing hydrolysis
Narrow therapeutic index: cardio and neurotoxic. (Blocks adenosine)

16
Q

Metacholine

A

Muscarinic receptor agonist used in bronchial challenge to diagnose asthma

Respiratory (3 decks)

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