Pharm 2a Flashcards
Teratogen risk categories
which is best?
which is worse?
A-D are acceptable with A being the least risk
X denotes that risk outweigh benefit.
New regualtion for labeling (preg/lactation labeling final rule)
what is removed?
now divided into what sections? 3?
what are the 4 phases of parturition?
what is major site of action of each stage?
phase 2 type of contractions?
3 ratio?
4which receptors? not due to?
amnion sythesizes what in late pregnancy? this is caused by increased what?
effects on maternal tissue limited by?
so in labor what happens? which causes?
what stims lung maturation in the fetus?
how?
Fetal cortisol
pro-inflammatory surfactant componentts in amniotic fluid. (cortisol stims production of placental CRH increased hormone production)
uterine relaxation maintained by factors that increase what?
uternine contraction result from what?
what is crucial for labor contractions across entire uterus?
Uterine gap junctions (connexins)
extensive waves of depolarization over large area uterus
Misoprostol
MOA?
clin indicatiosn (labor) 1 causes what to happen? useful for what 3
Contraindications?
Maternal SE?
fetal?
Dinoprostone
MOA?
Clin indications 3? abo- what weeks?
Contraindications-
mathernal SE- during abortion??
Fetal?
Carboprost
MOA?
Clin ind- 2
contraindicated?
Maternal SE? vaso? temp?
Oxytocin
MOA
clin use?
contraind? 2
maternal SE?
From rye fungus?
MOA?
effects/indicatiosn? 3 administered when?
Contraindications?
HIstorically?
what is given to promote lung maturation?
this increases what?
indications? between what weeks? with what signs?
corticosteroids
Surfactant
Which cortisol durgs will we use? 2
administered over how long?
b- doses? administration? intervals?
d- doses? administration? intervals?
what type of pneumoctyes do they work on?
Why do you not just administer cortisol for lung maturation?
in preborn babies with ARDS what can help survival?
placenta metabolizes (inactivates) to cortisone
mother can be admin cortisol without adverse fetal effect
NOTE: artificial surfactant can help survival
name for drugs that stimulate labor?
drugs that delay labor?
uterontonics
Tocolytics
