Pharm 201 - 214

Question 1

Dihydroxyacetone is found in which of the following products?
1 Rubber accelerators
2 Shampoos
3 Artificial nails
4 Hair dyes
5 Sunless tanning preparations

Answer 1

Dihydroxyacetone is the active ingredient in sunless tanning preparations. Upon oxidation it turns orange-brown and binds to the stratum corneum. Rubber accelerators contain mercaptobenthothiazole, carba mix, thiuram mix, or mercapto mix. Shampoos, especially “tear-free” ones, may contain cocamidopropyl betaine. Artificial nails may contain methyl methacrylate or ethyl acrylate. Hair dyes often have paraphenylenediamine.
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Question 2

What is the most likely congenital defect associated with isotretinoin therapy?
1 Atrial septal defect
2 Ventral septal defect
3 Cranial synostosis
4 Spina bifida
5 Phocomelia

Answer 2

Isotretinoin is thought to cause congenital defects by interfering with neural crest development. The most likely congenital defect is cranial synostosis.
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Question 3

The treatment of choice for erythema nodosum leprosum (ENL) is:
1 Thalidomide
2 Clofazamine
3 Rifampin
4 Rifampin and clofazamine
5 Isoniazid, rifampin and clofazamine

Answer 3

Erythema Nodosum Leprosum is a type 2 reaction of leprosy. It most commmonly ocurrs in lepromatous leprosy. Clinically, it presents as painful nodules and is associated with fever, malaise, anorexia, and arthralgias. The treatment of choice is thalidomide.
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Question 4

All of the following retinoids are excreted in the urine EXCEPT:
1 Bexarotene
2 Etretinate
3 Isotretinoin
4 Tretinoin
5 Acitretin

Answer 4

Bexarotene is excreted via hepatobiliary excretion. The others are excreted in bile and urine.
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Question 5

Which chemotherapeutic agent has been reported to cause acral sclerosis with Raynaud’s phenomenon?
1 Bleomycin
2 5-Fluorouracil
3 Methotrexate
4 Actinomycin
5 Interferon

Question 6

Which of the following vehicles is correctly defined
1 Ointment-water in oil emulsion
2 Gel-oil in water emulsion
3 Cream-Semisolid emulsion in alcohol base
4 Lotion/Solution-Cream in water
5 Foam - powder in cream

Question 7

Which of the following statements regarding the ocular toxicities of the antimalarial drugs is NOT true?
1 Premaculopathy associated with changes in visual fields without visual loss is reversible if the antimalarial is discontinued
2 True retinopathy is associated with “bull’s eye” pigment deposition, central scotoma, and diminished visual acuity
3 Risk of retinopathy is greatest for quinacrine, followed by chloroquine
4 Chloroquine and hydroxychloroquine should not be given together because of an additive effect on retinotoxicity
5 The 4-aminoquinolones may have significant associated ocular toxicity

Question 8

Which of the following statements is not true regarding the tetracycline antiobiotics?
1 Ingestion of zinc salts may impair absorption of tetracycline
2 Tetracycline is the most common cause of fixed drug eruption
3 Tetracycline is more phototoxic than demeclocycline
4 These antibiotics are effective against Mycoplasma infections
5 Tetracyclines are contraindicated in children less than 9 years of age

Question 9

The mechanism of action of mycophenolate mofetil most closely resembles that of what other drug?
1 Cyclophosphamide
2 Doxorubicin
3 Azathioprine
4 Hydroxyurea
5 Chlorambucil

Question 10

Imiquimod has proven beneficial in the treatment of all of the following lesions except:
1 Erythroplasia of Queyrat
2 Superficial basal cell carcinoma
3 Actinic keratoses
4 Squamous cell carcinoma
5 Extramammary Paget�s disease

Question 11

Which of the following is not associated with calcipotriene?
1 Inactivation by basic pH
2 Increase in interleukin-10
3 Decrease in interleukin-2
4 Potential risk for photosensitivity
5 Inhibition of NF-kB

Question 12

Raynaud’s phenomenon is a potential adverse effect of what chemotherapeutic agent?
1 5-fluorouracil
2 Doxorubicin
3 Bleomycin
4 Vinca alkaloids
5 Hydroxyurea

Question 13

All of the following topical antioxidants have demonstrated cutaneous anticarcinogenic effects in mice except:
1 Zinc
2 Vitamin C
3 Tea polyphenois
4 Vitamin E
5 Silymarin

Question 14

Which of the following medications is associated with anti-myeloperoxidase antibodies?
1 Isoniazid
2 Minocycline
3 Penicillamine
4 TNF-alpha inhibitors
5 Griseofulvin