Pharm 2 Flashcards
1
Q
Inotrope
A
changes contractility
2
Q
Chronotrope
A
changes heart rate
3
Q
dromotropic
A
changes conduction speed in AV node
4
Q
positive inotropes
A
- increase contractility
5
Q
digoxin
A
- weak positive inotrope
- cardiac glycoside
- inhibits NaKATPs
- increases CO
- acts on vagal nuclei to decrease HR = negative chronotrope
6
Q
dopamine
A
- positive inotrope
- catecholamine
- a and B1 agonist and dopaminergic receptors
- increases CO
7
Q
dobutamine
A
- positive inotrope
- synthetic catecholamine
- increases CO
- B1>B2 and mild a1 agonist
8
Q
pimobendan
A
- positive inotrope
- increases CO
- Ca2+ sensitizer
- increase affinity of troponin C for Ca2+ - sensitizes the contractile apparatus to enhance contractility
9
Q
anti-arrhythmics goal
A
restore abnormal heart rhythms to more normal
10
Q
Class 1A
A
- quinidine, procainamide
- black fast Na+ channels
- prolongs AP
- makes cell less excitable
11
Q
Class 1B
A
- lidocaine, mexiletine
- block fast Na+ channels
- shorten AP
12
Q
Class 1C
A
- not on exam?
- flecainide, propafenone
- block fast Na+ channel
- no obvious change AP
13
Q
class II
A
- atenolol, propranolol, esmolol, solatol
- B blockers
- decrease HR and contractility
14
Q
Class III
A
- solatol, amiodorone
- K+ channel blockers
- delay depolarization, leads to increase in AP, makes cell less excitable
15
Q
Class IV
A
- verapamil, diltiazem, amlodipine
- Ca2+ channel blockers
- decrease HR and contractility
