PHARM Flashcards
1
Q
action of most ant-epileptics
A
- Gaba agonist (Benzos)
- Glutamate modulation
- Na channel modulation (blocker) (phenytoin)
2
Q
IN/Bucc Midaz dose
A
-0.2-0.3 mg/kg/dose
max 10mg (5mg per nostril)
3
Q
phenytoin
A
- 20mg/kg IV or IO over 20min (1mg/kg/min)
- max dose 40 mg/kg
- If pt is already on it, consider other agent
- ** not compatible with D10
- negative inotrope
- consider filtering
- Too much can cause seizures
4
Q
Fosphenytoin
A
- prodrug of phenytoin
- IM or IV
- 20mg/kg same as phenytoin
- can be given faster (7-8min), less interactions
5
Q
Phenobarbital
A
- Gaba agonist (barbiturate)
- 20mg/kg IV over 20min
- causes resp depression, bronchospasm, hypotension (relative to administration rate)
6
Q
Levetiracetam (keppra)
A
- likely inhibits calcium channels
- 60mg/kg PO or IV
- sedating, vomiting
7
Q
Valproic Acid
A
- special access drug
- Gaba agonist, blocks Na channels
- 20-40 mg/kg
- hypotension, thrombocytopenia
8
Q
Ketamine
A
- decrease glutamate
- Dose 2mg/kg, 10-60mcg/kg/min IV infusion
- Uses: analgesia, sedation, bronchodilator, considered in seizure (status)
9
Q
Propofol
A
- gaba agonist, decreases glutamate
- use: sedation, refractory status (caution in pris: met acid, refractory VT, MODs, rhabdo)
10
Q
how long after prostin administration is apnea likely to present
A
4-6hrs
-therefore if starting prostin and you have a long transport intubation is suggested. If prostin has already been started by sending, apnea is less likely
11
Q
Neonatal TFI
A
Day 0 60-80 ml/kg/day Day 1 80-100 ml/kg/day Day 2 100-120 ml/kg/day Day 3 120-140 ml/kg/day Day 4 150 ml/kg/day
12
Q
> 24 hr - < 1 wk electrolyte requirements
A
Na, K, Cl 1-2 mEq/kg/day
13
Q
> 1 wk electrolyte requirements
A
Na and Cl 2-3 mEq/kg/day
14
Q
1st 24 hr electrolyte requirements
A
Just D10W due to poor renal function
